Names & Taxonomy
- Uniprot ID:
- P26951
- Entry Name:
- IL3RA_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
- Gene Names:
- IL3RA IL3R
- Gene Names Primary:
- IL3RA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 378
- Sequence:
- MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- This is a receptor for interleukin-3.
- Cross Reference Drug Bank:
- DB00020
- Gene Ontology Go:
- integral component of membrane
intracellular
plasma membrane
interleukin-3 receptor activity
activation of MAPKK activity
axon guidance
cellular response to interleukin-3
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interleukin-3-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cellular response to interleukin-3
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interleukin-3-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- interleukin-3 receptor activity
- Gene Ontology Cellular Component:
- integral component of membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix