Names & Taxonomy

Uniprot ID:
P26951
Entry Name:
IL3RA_HUMAN
Status:
reviewed
Protein Names:
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
Gene Names:
IL3RA IL3R
Gene Names Primary:
IL3RA
Organism:
Homo sapiens (Human)

Structure

Length:
378
Sequence:
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
This is a receptor for interleukin-3.
Cross Reference Drug Bank:
DB00020
Gene Ontology Go:
integral component of membrane
intracellular
plasma membrane
interleukin-3 receptor activity
activation of MAPKK activity
axon guidance
cellular response to interleukin-3
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interleukin-3-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
axon guidance
cellular response to interleukin-3
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interleukin-3-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
interleukin-3 receptor activity
Gene Ontology Cellular Component:
integral component of membrane
intracellular
plasma membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1833064 7887951 19109256 14702039 15772651 15489334