Names & Taxonomy
- Uniprot ID:
- P25098
- Entry Name:
- ARBK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
- Gene Names:
- ADRBK1 BARK BARK1 GRK2
- Gene Names Primary:
- ADRBK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 689
- Sequence:
- MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain.
- Active Site:
- ACT_SITE 317 317 Proton acceptor.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- cytoplasm
cytosol
membrane
plasma membrane
primary cilium
alpha-2A adrenergic receptor binding
ATP binding
beta-adrenergic receptor kinase activity
Edg-2 lysophosphatidic acid receptor binding
G-protein coupled receptor kinase activity
protein kinase activity
activation of phospholipase C activity
cardiac muscle contraction
desensitization of G-protein coupled receptor protein signaling pathway
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
heart development
innate immune response
negative regulation of striated muscle contraction
negative regulation of the force of heart contraction by chemical signal
neurotrophin TRK receptor signaling pathway
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of catecholamine secretion
receptor internalization
signal transduction
tachykinin receptor signaling pathway
viral entry into host cell
viral genome replication - Gene Ontology Biological Process:
- activation of phospholipase C activity
cardiac muscle contraction
desensitization of G-protein coupled receptor protein signaling pathway
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
heart development
innate immune response
negative regulation of striated muscle contraction
negative regulation of the force of heart contraction by chemical signal
neurotrophin TRK receptor signaling pathway
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of catecholamine secretion
receptor internalization
signal transduction
tachykinin receptor signaling pathway
viral entry into host cell
viral genome replication - Gene Ontology Molecular Function:
- alpha-2A adrenergic receptor binding
ATP binding
beta-adrenergic receptor kinase activity
Edg-2 lysophosphatidic acid receptor binding
G-protein coupled receptor kinase activity
protein kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
membrane
plasma membrane
primary cilium - Keywords:
- 3D-structure
ATP-binding
Cell membrane
Complete proteome
Cytoplasm
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- P21462; Q9Y2X7; Q00987; P0CG48