Names & Taxonomy

Uniprot ID:
P25090
Entry Name:
FPR2_HUMAN
Status:
reviewed
Protein Names:
N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP)
Gene Names:
FPR2 FPRH1 FPRL1 LXA4R
Gene Names Primary:
FPR2
Organism:
Homo sapiens (Human)

Structure

Length:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
Gene Ontology Go:
integral component of membrane
plasma membrane
G-protein coupled receptor activity
N-formyl peptide receptor activity
cell adhesion
chemotaxis
G-protein coupled receptor signaling pathway
inflammatory response
movement of cell or subcellular component
Gene Ontology Biological Process:
cell adhesion
chemotaxis
G-protein coupled receptor signaling pathway
inflammatory response
movement of cell or subcellular component
Gene Ontology Molecular Function:
G-protein coupled receptor activity
N-formyl peptide receptor activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Cell membrane
Chemotaxis
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1612600 1511907 1374236 1373134 7505609 9547339 14702039 15057824 15489334 9151906