Names & Taxonomy
- Uniprot ID:
- P25090
- Entry Name:
- FPR2_HUMAN
- Status:
- reviewed
- Protein Names:
- N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP)
- Gene Names:
- FPR2 FPRH1 FPRL1 LXA4R
- Gene Names Primary:
- FPR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
- Gene Ontology Go:
- integral component of membrane
plasma membrane
G-protein coupled receptor activity
N-formyl peptide receptor activity
cell adhesion
chemotaxis
G-protein coupled receptor signaling pathway
inflammatory response
movement of cell or subcellular component - Gene Ontology Biological Process:
- cell adhesion
chemotaxis
G-protein coupled receptor signaling pathway
inflammatory response
movement of cell or subcellular component - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
N-formyl peptide receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Chemotaxis
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix