Names & Taxonomy
- Uniprot ID:
- P24666
- Entry Name:
- PPAC_HUMAN
- Status:
- reviewed
- Protein Names:
- Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)
- Gene Names:
- ACP1
- Gene Names Primary:
- ACP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 158
- Sequence:
- MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; A phosphate monoester + H(2)O = an alcohol + phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by sulfhydryl reagents.
- Active Site:
- ACT_SITE 13 13 Nucleophile.
- Cross Reference Drug Bank:
- DB00173
- Gene Ontology Go:
- cytoplasm
cytoplasmic side of plasma membrane
extracellular exosome
acid phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity - Gene Ontology Molecular Function:
- acid phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic side of plasma membrane
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome - Interacts With:
- Itself