Names & Taxonomy

Uniprot ID:
P24557
Entry Name:
THAS_HUMAN
Status:
reviewed
Protein Names:
Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1)
Gene Names:
TBXAS1 CYP5 CYP5A1
Gene Names Primary:
TBXAS1
Organism:
Homo sapiens (Human)

Structure

Length:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Catalytic Activity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB01207 DB00795
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
thromboxane-A synthase activity
arachidonic acid metabolic process
cyclooxygenase pathway
icosanoid metabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
cyclooxygenase pathway
icosanoid metabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
thromboxane-A synthase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Heme
Iron
Isomerase
Lipid biosynthesis
Lipid metabolism
Membrane
Metal-binding
Monooxygenase
Oxidoreductase
Polymorphism
Prostaglandin biosynthesis
Prostaglandin metabolism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1714723 1730669 7925341 11465543 14702039 12853948 15489334 2043115 2195994 8366093 6101498 24275569 25944712 10391209 10391210 12721789 16959974 18264100