Names & Taxonomy
- Uniprot ID:
- P24557
- Entry Name:
- THAS_HUMAN
- Status:
- reviewed
- Protein Names:
- Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1)
- Gene Names:
- TBXAS1 CYP5 CYP5A1
- Gene Names Primary:
- TBXAS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 533
- Sequence:
- MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Catalytic Activity:
- (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB01207 DB00795
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
thromboxane-A synthase activity
arachidonic acid metabolic process
cyclooxygenase pathway
icosanoid metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
cyclooxygenase pathway
icosanoid metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
thromboxane-A synthase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Heme
Iron
Isomerase
Lipid biosynthesis
Lipid metabolism
Membrane
Metal-binding
Monooxygenase
Oxidoreductase
Polymorphism
Prostaglandin biosynthesis
Prostaglandin metabolism
Reference proteome
Transmembrane
Transmembrane helix