Names & Taxonomy

Uniprot ID:
P24046
Entry Name:
GBRR1_HUMAN
Status:
reviewed
Protein Names:
Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABA(C) receptor)
Gene Names:
GABRR1
Gene Names Primary:
GABRR1
Organism:
Homo sapiens (Human)

Structure

Length:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
Cross Reference Drug Bank:
DB00546 DB01558 DB01594 DB01559 DB00829 DB01215 DB01567 DB00690 DB00801 DB00683 DB01595 DB00842 DB01588 DB01589 DB00231 DB00897
Gene Ontology Go:
cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission
transmembrane transport
transport
Gene Ontology Biological Process:
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission
transmembrane transport
transport
Gene Ontology Molecular Function:
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
Gene Ontology Cellular Component:
cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
Keywords:
Alternative splicing
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Postsynaptic cell membrane
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
1849271 14702039 14574404 15489334