Names & Taxonomy
- Uniprot ID:
- P24046
- Entry Name:
- GBRR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABA(C) receptor)
- Gene Names:
- GABRR1
- Gene Names Primary:
- GABRR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 479
- Sequence:
- MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
- Cross Reference Drug Bank:
- DB00546 DB01558 DB01594 DB01559 DB00829 DB01215 DB01567 DB00690 DB00801 DB00683 DB01595 DB00842 DB01588 DB01589 DB00231 DB00897
- Gene Ontology Go:
- cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission
transmembrane transport
transport - Gene Ontology Biological Process:
- gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission
transmembrane transport
transport - Gene Ontology Molecular Function:
- chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity - Gene Ontology Cellular Component:
- cell junction
chloride channel complex
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Postsynaptic cell membrane
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport