Names & Taxonomy
- Uniprot ID:
- P23945
- Entry Name:
- FSHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor)
- Gene Names:
- FSHR LGR1
- Gene Names Primary:
- FSHR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 695
- Sequence:
- MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.
- Cross Reference Drug Bank:
- DB00097 DB00066 DB00032 DB04786 DB00094
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
plasma membrane
follicle-stimulating hormone receptor activity
G-protein coupled peptide receptor activity
activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
female gamete generation
female gonad development
follicle-stimulating hormone signaling pathway
G-protein coupled receptor signaling pathway
gonad development
hormone-mediated signaling pathway
male gonad development
positive regulation of ERK1 and ERK2 cascade
positive regulation of phosphatidylinositol 3-kinase signaling
primary ovarian follicle growth
regulation of osteoclast differentiation
regulation of protein kinase A signaling
spermatogenesis - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
female gamete generation
female gonad development
follicle-stimulating hormone signaling pathway
gonad development
G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
male gonad development
positive regulation of ERK1 and ERK2 cascade
positive regulation of phosphatidylinositol 3-kinase signaling
primary ovarian follicle growth
regulation of osteoclast differentiation
regulation of protein kinase A signaling
spermatogenesis - Gene Ontology Molecular Function:
- follicle-stimulating hormone receptor activity
G-protein coupled peptide receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Leucine-rich repeat
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P27348