Names & Taxonomy
- Uniprot ID:
- P23919
- Entry Name:
- KTHY_HUMAN
- Status:
- reviewed
- Protein Names:
- Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
- Gene Names:
- DTYMK CDC8 TMPK TYMK
- Gene Names Primary:
- DTYMK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 212
- Sequence:
- MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the conversion of dTMP to dTDP.
- Pathway:
- Pyrimidine metabolism; dTTP biosynthesis.
- Catalytic Activity:
- ATP + dTMP = ADP + dTDP.
- Gene Ontology Go:
- cytosol
mitochondrial intermembrane space
mitochondrial matrix
ATP binding
nucleoside phosphate kinase activity
thymidylate kinase activity
uridylate kinase activity
cell cycle
cell proliferation
cellular response to growth factor stimulus
dTDP biosynthetic process
dTTP biosynthetic process
dUDP biosynthetic process
myoblast differentiation
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside monophosphate phosphorylation
nucleotide phosphorylation
response to cadmium ion
response to estrogen
small molecule metabolic process - Gene Ontology Biological Process:
- cell cycle
cell proliferation
cellular response to growth factor stimulus
dTDP biosynthetic process
dTTP biosynthetic process
dUDP biosynthetic process
myoblast differentiation
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside monophosphate phosphorylation
nucleotide phosphorylation
response to cadmium ion
response to estrogen
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
nucleoside phosphate kinase activity
thymidylate kinase activity
uridylate kinase activity - Gene Ontology Cellular Component:
- cytosol
mitochondrial intermembrane space
mitochondrial matrix - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Kinase
Nucleotide biosynthesis
Nucleotide-binding
Reference proteome
Transferase