Names & Taxonomy
- Uniprot ID:
- P23470
- Entry Name:
- PTPRG_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)
- Gene Names:
- PTPRG PTPG
- Gene Names Primary:
- PTPRG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1445
- Sequence:
- MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAESMESLV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Possesses tyrosine phosphatase activity.
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Active Site:
- ACT_SITE 1060 1060 Phosphocysteine intermediate.
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
identical protein binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
negative regulation of epithelial cell migration
peptidyl-tyrosine dephosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- negative regulation of epithelial cell migration
peptidyl-tyrosine dephosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- identical protein binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P35222