Names & Taxonomy
- Uniprot ID:
- P23416
- Entry Name:
- GLRA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine receptor subunit alpha-2
- Gene Names:
- GLRA2
- Gene Names Primary:
- GLRA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 452
- Sequence:
- MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane
Function
- Function:
- Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: Note=For isoform Alpha-2* homopentamers, a concentration of about 66 uM glycine results in half-maximal channel conductance. For isoform Alpha-2B homopentamers, a concentration of about 34 uM glycine results in half-maximal channel conductance.;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by strychnine (PubMed:2155780, PubMed:15302677). Inhibited by picrotoxin (PubMed:15302677). Channel activity is potentiated by 10-100 uM Zn(2+) (PubMed:15302677, PubMed:16144831, PubMed:23895467). Channel activity is marginally increased by 50 mM ethanol; it is strongly increased by a combination of 0.5 uM Zn(2+) and 50 mM ethanol (PubMed:23895467). Channel activity is inhibited by 100-1000 uM Zn(2+) (PubMed:15302677).
- Cross Reference Drug Bank:
- DB00898 DB00145 DB00431
- Gene Ontology Go:
- cell junction
cell projection
chloride channel complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
extracellular-glycine-gated chloride channel activity
glycine binding
glycine-gated chloride ion channel activity
metal ion binding
cellular response to amino acid stimulus
cellular response to ethanol
cellular response to zinc ion
chloride transmembrane transport
ion transmembrane transport
neuropeptide signaling pathway
response to amino acid
spinal cord development
synapse assembly
synaptic transmission, glycinergic
transmembrane transport - Gene Ontology Biological Process:
- cellular response to amino acid stimulus
cellular response to ethanol
cellular response to zinc ion
chloride transmembrane transport
ion transmembrane transport
neuropeptide signaling pathway
response to amino acid
spinal cord development
synapse assembly
synaptic transmission, glycinergic
transmembrane transport - Gene Ontology Molecular Function:
- extracellular-glycine-gated chloride channel activity
glycine binding
glycine-gated chloride ion channel activity
metal ion binding - Gene Ontology Cellular Component:
- cell junction
cell projection
chloride channel complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Cell projection
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Metal-binding
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Zinc