Names & Taxonomy

Uniprot ID:
P23368
Entry Name:
MAOM_HUMAN
Status:
reviewed
Protein Names:
NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)
Gene Names:
ME2
Gene Names Primary:
ME2
Organism:
Homo sapiens (Human)

Structure

Length:
584
Sequence:
MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Catalytic Activity:
(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.; Oxaloacetate = pyruvate + CO(2).
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; ; Note=Divalent metal cations. Prefers magnesium or manganese.;
Enzyme Regulation:
ENZYME REGULATION: Subject to allosteric activation by fumarate.
Active Site:
ACT_SITE 112 112 Proton donor.; ACT_SITE 183 183 Proton acceptor.
Gene Ontology Go:
intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity
malate metabolic process
regulation of NADP metabolic process
Gene Ontology Biological Process:
malate metabolic process
regulation of NADP metabolic process
Gene Ontology Molecular Function:
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity
Gene Ontology Cellular Component:
intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
Keywords:
3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Direct protein sequencing
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide

Publication

PubMed ID:
1993674 11401430 14702039 16177791 15489334 12665801 19608861 21269460 24275569 25944712 10467136 10700286 12121650 12962632