Names & Taxonomy
- Uniprot ID:
- P23368
- Entry Name:
- MAOM_HUMAN
- Status:
- reviewed
- Protein Names:
- NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)
- Gene Names:
- ME2
- Gene Names Primary:
- ME2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 584
- Sequence:
- MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Catalytic Activity:
- (S)-malate + NAD(+) = pyruvate + CO(2) + NADH.; Oxaloacetate = pyruvate + CO(2).
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; ; Note=Divalent metal cations. Prefers magnesium or manganese.;
- Enzyme Regulation:
- ENZYME REGULATION: Subject to allosteric activation by fumarate.
- Active Site:
- ACT_SITE 112 112 Proton donor.; ACT_SITE 183 183 Proton acceptor.
- Gene Ontology Go:
- intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity
malate metabolic process
regulation of NADP metabolic process - Gene Ontology Biological Process:
- malate metabolic process
regulation of NADP metabolic process - Gene Ontology Molecular Function:
- electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malic enzyme activity
metal ion binding
NAD binding
oxaloacetate decarboxylase activity - Gene Ontology Cellular Component:
- intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Direct protein sequencing
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide