Names & Taxonomy
- Uniprot ID:
- P23284
- Entry Name:
- PPIB_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
- Gene Names:
- PPIB CYPB
- Gene Names Primary:
- PPIB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 216
- Sequence:
- MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum lumen
Function
- Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Cyclosporin A (CsA) inhibits CYPB.
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum lumen
extracellular exosome
focal adhesion
macromolecular complex
melanosome
membrane
nucleus
perinuclear region of cytoplasm
smooth endoplasmic reticulum
peptide binding
peptidyl-prolyl cis-trans isomerase activity
poly(A) RNA binding
protein complex binding
RNA polymerase binding
unfolded protein binding
bone development
chaperone-mediated protein folding
extracellular matrix organization
positive regulation by host of viral genome replication
positive regulation by host of viral process
positive regulation of multicellular organism growth
protein peptidyl-prolyl isomerization
protein stabilization - Gene Ontology Biological Process:
- bone development
chaperone-mediated protein folding
extracellular matrix organization
positive regulation by host of viral genome replication
positive regulation by host of viral process
positive regulation of multicellular organism growth
protein peptidyl-prolyl isomerization
protein stabilization - Gene Ontology Molecular Function:
- peptide binding
peptidyl-prolyl cis-trans isomerase activity
poly(A) RNA binding
protein complex binding
RNA polymerase binding
unfolded protein binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum lumen
extracellular exosome
focal adhesion
macromolecular complex
melanosome
membrane
nucleus
perinuclear region of cytoplasm
smooth endoplasmic reticulum - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cyclosporin
Direct protein sequencing
Disease mutation
Dwarfism
Endoplasmic reticulum
Glycoprotein
Isomerase
Osteogenesis imperfecta
Polymorphism
Reference proteome
Rotamase
Signal - Interacts With:
- Q9WMX2; Q8N9N5; P13667; P40855; O43765; Q9UMX0; Q9UMX0-2