Names & Taxonomy
- Uniprot ID:
- P22392
- Entry Name:
- NDKB_HUMAN
- Status:
- reviewed
- Protein Names:
- Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)
- Gene Names:
- NME2 NM23B
- Gene Names Primary:
- NME2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 152
- Sequence:
- MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
- Catalytic Activity:
- ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.; ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 118 118 Pros-phosphohistidine intermediate.
- Cross Reference Drug Bank:
- DB00718 DB00709 DB00300
- Gene Ontology Go:
- cell periphery
cytoplasm
cytosol
extracellular exosome
lamellipodium
nucleus
ruffle
ATP binding
DNA binding
metal ion binding
nucleoside diphosphate kinase activity
protein histidine kinase activity
transcription factor activity, sequence-specific DNA binding
cell adhesion
CTP biosynthetic process
GTP biosynthetic process
integrin-mediated signaling pathway
mitophagy in response to mitochondrial depolarization
negative regulation of apoptotic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside triphosphate biosynthetic process
positive regulation of epithelial cell proliferation
positive regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
purine nucleotide metabolic process
pyrimidine nucleotide metabolic process
regulation of epidermis development
regulation of transcription, DNA-templated
small molecule metabolic process
transcription, DNA-templated
UTP biosynthetic process - Gene Ontology Biological Process:
- cell adhesion
CTP biosynthetic process
GTP biosynthetic process
integrin-mediated signaling pathway
mitophagy in response to mitochondrial depolarization
negative regulation of apoptotic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside triphosphate biosynthetic process
positive regulation of epithelial cell proliferation
positive regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
purine nucleotide metabolic process
pyrimidine nucleotide metabolic process
regulation of epidermis development
regulation of transcription, DNA-templated
small molecule metabolic process
transcription, DNA-templated
UTP biosynthetic process - Gene Ontology Molecular Function:
- ATP binding
DNA binding
metal ion binding
nucleoside diphosphate kinase activity
protein histidine kinase activity
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- cell periphery
cytoplasm
cytosol
extracellular exosome
lamellipodium
nucleus
ruffle - Keywords:
- 3D-structure
ATP-binding
Acetylation
Activator
Alternative splicing
Cell projection
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Kinase
Magnesium
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Nucleus
Reference proteome
Transcription
Transcription regulation
Transferase - Interacts With:
- O14713-1; P15531