Names & Taxonomy
- Uniprot ID:
- P22307
- Entry Name:
- NLTP_HUMAN
- Status:
- reviewed
- Protein Names:
- Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X)
- Gene Names:
- SCP2
- Gene Names Primary:
- SCP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 547
- Sequence:
- MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQLQPGNAKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
- Catalytic Activity:
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
intracellular membrane-bounded organelle
membrane
mitochondrion
nucleoplasm
peroxisomal matrix
peroxisome
protein complex
cholesterol binding
fatty-acyl-CoA binding
long-chain fatty acyl-CoA binding
oleic acid binding
phosphatidylinositol transporter activity
propanoyl-CoA C-acyltransferase activity
receptor binding
sterol transporter activity
alpha-linolenic acid metabolic process
bile acid biosynthetic process
bile acid metabolic process
cellular lipid metabolic process
cholesterol transport
fatty acid beta-oxidation using acyl-CoA oxidase
inositol trisphosphate biosynthetic process
lipid hydroperoxide transport
peroxisome organization
phospholipid transport
positive regulation of intracellular cholesterol transport
positive regulation of steroid metabolic process
progesterone biosynthetic process
protein localization to plasma membrane
small molecule metabolic process
steroid biosynthetic process
unsaturated fatty acid metabolic process - Gene Ontology Biological Process:
- alpha-linolenic acid metabolic process
bile acid biosynthetic process
bile acid metabolic process
cellular lipid metabolic process
cholesterol transport
fatty acid beta-oxidation using acyl-CoA oxidase
inositol trisphosphate biosynthetic process
lipid hydroperoxide transport
peroxisome organization
phospholipid transport
positive regulation of intracellular cholesterol transport
positive regulation of steroid metabolic process
progesterone biosynthetic process
protein localization to plasma membrane
small molecule metabolic process
steroid biosynthetic process
unsaturated fatty acid metabolic process - Gene Ontology Molecular Function:
- cholesterol binding
fatty-acyl-CoA binding
long-chain fatty acyl-CoA binding
oleic acid binding
phosphatidylinositol transporter activity
propanoyl-CoA C-acyltransferase activity
receptor binding
sterol transporter activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
intracellular membrane-bounded organelle
membrane
mitochondrion
nucleoplasm
peroxisomal matrix
peroxisome
protein complex - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Alternative initiation
Alternative promoter usage
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid transport
Lipid-binding
Mitochondrion
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transport - Interacts With:
- Q03135; P49817; Q15645