Names & Taxonomy
- Uniprot ID:
- P22303
- Entry Name:
- ACES_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetylcholinesterase (AChE) (EC 3.1.1.7)
- Gene Names:
- ACHE
- Gene Names Primary:
- ACHE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 614
- Sequence:
- MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse
Function
- Function:
- Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
- Catalytic Activity:
- Acetylcholine + H(2)O = choline + acetate.
- Active Site:
- ACT_SITE 234 234 Acyl-ester intermediate.; ACT_SITE 365 365 Charge relay system.; ACT_SITE 478 478 Charge relay system.
- Cross Reference Drug Bank:
- DB03128 DB01122 DB00122 DB01245 DB00944 DB08996 DB00449 DB00843 DB01010 DB01364 DB00674 DB00483 DB00677 DB00358 DB00805 DB01400 DB00981 DB00733 DB00545 DB00989 DB01199
- Gene Ontology Go:
- anchored component of membrane
basal lamina
cell junction
cell surface
extracellular region
extracellular space
Golgi apparatus
membrane
neuromuscular junction
nucleus
perinuclear region of cytoplasm
plasma membrane
synapse
synaptic cleft
acetylcholine binding
acetylcholinesterase activity
beta-amyloid binding
cholinesterase activity
collagen binding
hydrolase activity
laminin binding
protein homodimerization activity
serine hydrolase activity
acetylcholine catabolic process
acetylcholine catabolic process in synaptic cleft
amyloid precursor protein metabolic process
cell adhesion
cell proliferation
DNA replication
glycerophospholipid biosynthetic process
muscle organ development
negative regulation of synaptic transmission, cholinergic
nervous system development
neurotransmitter biosynthetic process
neurotransmitter receptor biosynthetic process
osteoblast development
phosphatidylcholine biosynthetic process
phospholipid metabolic process
positive regulation of protein secretion
protein tetramerization
receptor internalization
regulation of receptor recycling
response to wounding
retina development in camera-type eye
small molecule metabolic process
synapse assembly
synaptic transmission - Gene Ontology Biological Process:
- acetylcholine catabolic process
acetylcholine catabolic process in synaptic cleft
amyloid precursor protein metabolic process
cell adhesion
cell proliferation
DNA replication
glycerophospholipid biosynthetic process
muscle organ development
negative regulation of synaptic transmission, cholinergic
nervous system development
neurotransmitter biosynthetic process
neurotransmitter receptor biosynthetic process
osteoblast development
phosphatidylcholine biosynthetic process
phospholipid metabolic process
positive regulation of protein secretion
protein tetramerization
receptor internalization
regulation of receptor recycling
response to wounding
retina development in camera-type eye
small molecule metabolic process
synapse assembly
synaptic transmission - Gene Ontology Molecular Function:
- acetylcholine binding
acetylcholinesterase activity
beta-amyloid binding
cholinesterase activity
collagen binding
hydrolase activity
laminin binding
protein homodimerization activity
serine hydrolase activity - Gene Ontology Cellular Component:
- anchored component of membrane
basal lamina
cell junction
cell surface
extracellular region
extracellular space
Golgi apparatus
membrane
neuromuscular junction
nucleus
perinuclear region of cytoplasm
plasma membrane
synapse
synaptic cleft - Keywords:
- 3D-structure
Alternative splicing
Blood group antigen
Cell junction
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Neurotransmitter degradation
Nucleus
Polymorphism
Reference proteome
Secreted
Serine esterase
Signal
Synapse - Interacts With:
- Q9Y215; P06733; P63244