Names & Taxonomy

Uniprot ID:
P22061
Entry Name:
PIMT_HUMAN
Status:
reviewed
Protein Names:
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)
Gene Names:
PCMT1
Gene Names Primary:
PCMT1
Organism:
Homo sapiens (Human)

Structure

Length:
227
Sequence:
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Catalytic Activity:
S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.
Active Site:
ACT_SITE 60 60
Gene Ontology Go:
cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
extracellular vesicle
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
cellular protein metabolic process
protein methylation
protein repair
Gene Ontology Biological Process:
cellular protein metabolic process
protein methylation
protein repair
Gene Ontology Molecular Function:
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
extracellular vesicle
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase
Interacts With:
Q13155; P49247

Publication

PubMed ID:
2684970 1339271 7592526 14702039 14574404 15489334 8914929 3167043 8074695 1998518 24275569 25944712 10496068 11792715 11847284 21269460