Names & Taxonomy
- Uniprot ID:
- P22061
- Entry Name:
- PIMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)
- Gene Names:
- PCMT1
- Gene Names Primary:
- PCMT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 227
- Sequence:
- MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
- Catalytic Activity:
- S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.
- Active Site:
- ACT_SITE 60 60
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
extracellular vesicle
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
cellular protein metabolic process
protein methylation
protein repair - Gene Ontology Biological Process:
- cellular protein metabolic process
protein methylation
protein repair - Gene Ontology Molecular Function:
- protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
extracellular vesicle - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase - Interacts With:
- Q13155; P49247