Names & Taxonomy
- Uniprot ID:
- P21796
- Entry Name:
- VDAC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
- Gene Names:
- VDAC1 VDAC
- Gene Names Primary:
- VDAC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 283
- Sequence:
- MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane
Function
- Function:
- Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by nitric oxide.
- Cross Reference Drug Bank:
- DB01375
- Gene Ontology Go:
- extracellular exosome
membrane
membrane raft
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrial outer membrane
mitochondrion
myelin sheath
nucleus
plasma membrane
pore complex
synaptic vesicle
ion channel binding
porin activity
protein kinase binding
voltage-gated anion channel activity
anion transport
apoptotic process
behavioral fear response
epithelial cell differentiation
learning
macroautophagy
macromitophagy
mitochondrial calcium ion transport
negative regulation of reactive oxygen species metabolic process
neuron-neuron synaptic transmission
regulation of mitophagy
viral process - Gene Ontology Biological Process:
- anion transport
apoptotic process
behavioral fear response
epithelial cell differentiation
learning
macroautophagy
macromitophagy
mitochondrial calcium ion transport
negative regulation of reactive oxygen species metabolic process
neuron-neuron synaptic transmission
regulation of mitophagy
viral process - Gene Ontology Molecular Function:
- ion channel binding
porin activity
protein kinase binding
voltage-gated anion channel activity - Gene Ontology Cellular Component:
- extracellular exosome
membrane
membrane raft
mitochondrial inner membrane
mitochondrial nucleoid
mitochondrial outer membrane
mitochondrion
myelin sheath
nucleus
plasma membrane
pore complex
synaptic vesicle - Keywords:
- 3D-structure
Acetylation
Apoptosis
Cell membrane
Complete proteome
Direct protein sequencing
Host-virus interaction
Ion transport
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion outer membrane
Phosphoprotein
Porin
Reference proteome
Transmembrane
Transmembrane beta strand
Transport
Ubl conjugation - Interacts With:
- Q7L3V2; P19367; Q14643
Publication
- PubMed ID:
- 8420959 10501981 10772903 14702039 15372022 15489334 2559745 1657034 7685903 7539795 10661876 11845315 15033708 16201016 17081983 18088087 18691976 18669648 19413330 19608861 20230784 20068231 21269460 21406692 22304920 22223895 22814378 23055042 24275569 25621951 21156174 25296756 25168729 25944712 18832158 18755977