Names & Taxonomy
- Uniprot ID:
- P21731
- Entry Name:
- TA2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
- Gene Names:
- TBXA2R
- Gene Names Primary:
- TBXA2R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 343
- Sequence:
- MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
- Cross Reference Drug Bank:
- DB01207
- Gene Ontology Go:
- acrosomal vesicle
cytosol
integral component of plasma membrane
plasma membrane
guanyl-nucleotide exchange factor activity
thromboxane A2 receptor activity
blood coagulation
G-protein coupled receptor signaling pathway
inflammatory response
platelet activation
positive regulation of angiogenesis
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of GTPase activity
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction
response to drug
response to lipopolysaccharide
response to nutrient
second-messenger-mediated signaling
thromboxane A2 signaling pathway - Gene Ontology Biological Process:
- blood coagulation
G-protein coupled receptor signaling pathway
inflammatory response
platelet activation
positive regulation of angiogenesis
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of GTPase activity
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction
response to drug
response to lipopolysaccharide
response to nutrient
second-messenger-mediated signaling
thromboxane A2 signaling pathway - Gene Ontology Molecular Function:
- guanyl-nucleotide exchange factor activity
thromboxane A2 receptor activity - Gene Ontology Cellular Component:
- acrosomal vesicle
cytosol
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q13162