Names & Taxonomy
- Uniprot ID:
- P21728
- Entry Name:
- DRD1_HUMAN
- Status:
- reviewed
- Protein Names:
- D(1A) dopamine receptor (Dopamine D1 receptor)
- Gene Names:
- DRD1
- Gene Names Primary:
- DRD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 446
- Sequence:
- MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
- Cross Reference Drug Bank:
- DB01614 DB01063 DB00543 DB00714 DB01238 DB06216 DB01200 DB00248 DB00477 DB01239 DB00568 DB00363 DB00988 DB01049 DB00696 DB00800 DB00875 DB00623 DB00502 DB04946 DB00458 DB01235 DB00589 DB00408 DB01403 DB00353 DB06148 DB00805 DB00370 DB00334 DB01267 DB01186 DB00850 DB00397 DB01621 DB00413 DB00420 DB01608 DB00777 DB01224 DB00734 DB00268 DB05271 DB01622 DB00679 DB01623 DB00508 DB00726 DB00246 DB01624
- Gene Ontology Go:
- axon terminus
caveola
ciliary membrane
dendritic shaft
dendritic spine head
dendritic spine neck
endoplasmic reticulum membrane
integral component of plasma membrane
neuronal cell body
nonmotile primary cilium
nucleus
plasma membrane
dopamine binding
dopamine neurotransmitter receptor activity
dopamine neurotransmitter receptor activity, coupled via Gs
drug binding
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adult walking behavior
astrocyte development
behavioral fear response
behavioral response to cocaine
calcium-mediated signaling
cellular response to catecholamine stimulus
cellular response to hypoxia
cellular response to insulin stimulus
cerebral cortex GABAergic interneuron migration
conditioned taste aversion
dentate gyrus development
dopamine metabolic process
dopamine transport
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
glucose import
grooming behavior
habituation
learning
long term synaptic depression
long-term synaptic potentiation
maternal behavior
mating behavior
memory
negative regulation of cell migration
negative regulation of circadian sleep/wake cycle, sleep
negative regulation of protein kinase activity
neuronal action potential
operant conditioning
orbitofrontal cortex development
peristalsis
phospholipase C-activating dopamine receptor signaling pathway
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of cAMP biosynthetic process
positive regulation of cell migration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of feeding behavior
positive regulation of long-term synaptic potentiation
positive regulation of membrane potential
positive regulation of potassium ion transport
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
protein import into nucleus
regulation of dopamine metabolic process
regulation of dopamine uptake involved in synaptic transmission
regulation of long-term neuronal synaptic plasticity
regulation of vasoconstriction
response to activity
response to amino acid
response to amphetamine
response to antidepressant
response to drug
response to estradiol
response to ethanol
response to food
response to morphine
response to nicotine
response to retinoic acid
sensitization
social behavior
striatum development
synapse assembly
synaptic transmission, dopaminergic
temperature homeostasis
transmission of nerve impulse
vasodilation
visual learning - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adult walking behavior
astrocyte development
behavioral fear response
behavioral response to cocaine
calcium-mediated signaling
cellular response to catecholamine stimulus
cellular response to hypoxia
cellular response to insulin stimulus
cerebral cortex GABAergic interneuron migration
conditioned taste aversion
dentate gyrus development
dopamine metabolic process
dopamine transport
glucose import
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
grooming behavior
habituation
learning
long term synaptic depression
long-term synaptic potentiation
maternal behavior
mating behavior
memory
negative regulation of cell migration
negative regulation of circadian sleep/wake cycle, sleep
negative regulation of protein kinase activity
neuronal action potential
operant conditioning
orbitofrontal cortex development
peristalsis
phospholipase C-activating dopamine receptor signaling pathway
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of cAMP biosynthetic process
positive regulation of cell migration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of feeding behavior
positive regulation of long-term synaptic potentiation
positive regulation of membrane potential
positive regulation of potassium ion transport
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
protein import into nucleus
regulation of dopamine metabolic process
regulation of dopamine uptake involved in synaptic transmission
regulation of long-term neuronal synaptic plasticity
regulation of vasoconstriction
response to activity
response to amino acid
response to amphetamine
response to antidepressant
response to drug
response to estradiol
response to ethanol
response to food
response to morphine
response to nicotine
response to retinoic acid
sensitization
social behavior
striatum development
synapse assembly
synaptic transmission, dopaminergic
temperature homeostasis
transmission of nerve impulse
vasodilation
visual learning - Gene Ontology Molecular Function:
- dopamine binding
dopamine neurotransmitter receptor activity
dopamine neurotransmitter receptor activity, coupled via Gs
drug binding - Gene Ontology Cellular Component:
- axon terminus
caveola
ciliary membrane
dendritic shaft
dendritic spine head
dendritic spine neck
endoplasmic reticulum membrane
integral component of plasma membrane
neuronal cell body
nonmotile primary cilium
nucleus
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
Endoplasmic reticulum
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix