Names & Taxonomy
- Uniprot ID:
- P21462
- Entry Name:
- FPR1_HUMAN
- Status:
- reviewed
- Protein Names:
- fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor)
- Gene Names:
- FPR1
- Gene Names Primary:
- FPR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).
- Cross Reference Drug Bank:
- DB00716
- Gene Ontology Go:
- endosome
integral component of membrane
plasma membrane
N-formyl peptide receptor activity
receptor activity
activation of MAPK activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
chemotaxis
G-protein coupled receptor signaling pathway
movement of cell or subcellular component
nitric oxide mediated signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
signal transduction - Gene Ontology Biological Process:
- activation of MAPK activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
chemotaxis
G-protein coupled receptor signaling pathway
movement of cell or subcellular component
nitric oxide mediated signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
signal transduction - Gene Ontology Molecular Function:
- N-formyl peptide receptor activity
receptor activity - Gene Ontology Cellular Component:
- endosome
integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Chemotaxis
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P25098; O15264