Names & Taxonomy
- Uniprot ID:
- P21397
- Entry Name:
- AOFA_HUMAN
- Status:
- reviewed
- Protein Names:
- Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A)
- Gene Names:
- MAOA
- Gene Names Primary:
- MAOA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 527
- Sequence:
- MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Function
- Function:
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
- Catalytic Activity:
- RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB00918 DB06774 DB00988 DB01363 DB03147 DB00614 DB01247 DB00601 DB01577 DB00805 DB01171 DB08804 DB00952 DB00184 DB06412 DB01626 DB00780 DB00191 DB00388 DB00397 DB00721 DB00852 DB00140 DB00953 DB01037 DB01104 DB00669 DB00624 DB00752 DB00315 DB00909
- Gene Ontology Go:
- integral component of membrane
mitochondrial outer membrane
mitochondrion
presynapse
flavin adenine dinucleotide binding
primary amine oxidase activity
serotonin binding
cellular biogenic amine metabolic process
dopamine catabolic process
neurotransmitter biosynthetic process
neurotransmitter catabolic process
neurotransmitter secretion
phenylethylamine metabolic process
serotonin metabolic process
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular biogenic amine metabolic process
dopamine catabolic process
neurotransmitter biosynthetic process
neurotransmitter catabolic process
neurotransmitter secretion
phenylethylamine metabolic process
serotonin metabolic process
small molecule metabolic process
synaptic transmission
xenobiotic metabolic process - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
primary amine oxidase activity
serotonin binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial outer membrane
mitochondrion
presynapse - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Catecholamine metabolism
Complete proteome
Direct protein sequencing
Disease mutation
FAD
Flavoprotein
Membrane
Mental retardation
Mitochondrion
Mitochondrion outer membrane
Neurotransmitter degradation
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix