Names & Taxonomy

Uniprot ID:
P21281
Entry Name:
VATB2_HUMAN
Status:
reviewed
Protein Names:
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)
Gene Names:
ATP6V1B2 ATP6B2 VPP3
Gene Names Primary:
ATP6V1B2
Organism:
Homo sapiens (Human)

Structure

Length:
511
Sequence:
MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Melanosome. Note=Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Function

Function:
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Cross Reference Drug Bank:
DB05260
Gene Ontology Go:
cytosol
endomembrane system
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
lysosomal membrane
melanosome
microvillus
myelin sheath
plasma membrane
proton-transporting V-type ATPase, V1 domain
ruffle
ATP binding
hydrogen ion transmembrane transporter activity
proton-transporting ATPase activity, rotational mechanism
ATP hydrolysis coupled proton transport
ATP metabolic process
cell redox homeostasis
cellular iron ion homeostasis
insulin receptor signaling pathway
ion transmembrane transport
proton transport
regulation of macroautophagy
transferrin transport
transmembrane transport
Gene Ontology Biological Process:
ATP hydrolysis coupled proton transport
ATP metabolic process
cell redox homeostasis
cellular iron ion homeostasis
insulin receptor signaling pathway
ion transmembrane transport
proton transport
regulation of macroautophagy
transferrin transport
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
hydrogen ion transmembrane transporter activity
proton-transporting ATPase activity, rotational mechanism
Gene Ontology Cellular Component:
cytosol
endomembrane system
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
lysosomal membrane
melanosome
microvillus
myelin sheath
plasma membrane
proton-transporting V-type ATPase, V1 domain
ruffle
Keywords:
Complete proteome
Disease mutation
Hydrogen ion transport
Hydrolase
Ion transport
Membrane
Reference proteome
Transport
Interacts With:
P15884

Publication

PubMed ID:
1373501 7945239 14702039 15489334 7706273 2145275 12643545 17081065 21269460 24913193 25915598 25944712