Names & Taxonomy

Uniprot ID:
P21266
Entry Name:
GSTM3_HUMAN
Status:
reviewed
Protein Names:
Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)
Gene Names:
GSTM3 GST5
Gene Names Primary:
GSTM3
Organism:
Homo sapiens (Human)

Structure

Length:
225
Sequence:
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLDFPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
Catalytic Activity:
RX + glutathione = HX + R-S-glutathione.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene
Cross Reference Drug Bank:
DB00143 DB00163
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nucleus
sperm fibrous sheath
enzyme binding
glutathione binding
glutathione transferase activity
identical protein binding
protein homodimerization activity
cellular detoxification of nitrogen compound
establishment of blood-nerve barrier
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
response to estrogen
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular detoxification of nitrogen compound
establishment of blood-nerve barrier
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
response to estrogen
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
enzyme binding
glutathione binding
glutathione transferase activity
identical protein binding
protein homodimerization activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
nucleus
sperm fibrous sheath
Keywords:
3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Reference proteome
Transferase
Interacts With:
Itself

Publication

PubMed ID:
2345169 9882431 15489334 8373352 8218382 21269460 10587441