Names & Taxonomy
- Uniprot ID:
- P21266
- Entry Name:
- GSTM3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)
- Gene Names:
- GSTM3 GST5
- Gene Names Primary:
- GSTM3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 225
- Sequence:
- MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLDFPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene
- Cross Reference Drug Bank:
- DB00143 DB00163
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
sperm fibrous sheath
enzyme binding
glutathione binding
glutathione transferase activity
identical protein binding
protein homodimerization activity
cellular detoxification of nitrogen compound
establishment of blood-nerve barrier
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
response to estrogen
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular detoxification of nitrogen compound
establishment of blood-nerve barrier
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
response to estrogen
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme binding
glutathione binding
glutathione transferase activity
identical protein binding
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus
sperm fibrous sheath - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Reference proteome
Transferase - Interacts With:
- Itself