Names & Taxonomy

Uniprot ID:
P20823
Entry Name:
HNF1A_HUMAN
Status:
reviewed
Protein Names:
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Gene Names:
HNF1A TCF1
Gene Names Primary:
HNF1A
Organism:
Homo sapiens (Human)

Structure

Length:
631
Sequence:
MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSSQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Gene Ontology Go:
cytoplasm
nucleus
protein complex
DNA binding
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
glucose homeostasis
glucose import
insulin secretion
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
renal glucose absorption
transcription from RNA polymerase II promoter
Gene Ontology Biological Process:
glucose homeostasis
glucose import
insulin secretion
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription initiation from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
renal glucose absorption
transcription from RNA polymerase II promoter
Gene Ontology Molecular Function:
DNA binding
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
Gene Ontology Cellular Component:
cytoplasm
nucleus
protein complex
Keywords:
3D-structure
Activator
Alternative splicing
Complete proteome
DNA-binding
Diabetes mellitus
Disease mutation
Homeobox
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Interacts With:
Q9Y463; Q92786

Publication

PubMed ID:
1707031 7900999 8945470 16541075 15489334 24275569 12453420 16930618 9166684 9287053 9287055 9313763 9392505 9032114 9075818 9075819 9133564 9112026 9097962 9604876 9754819 9867222 9626139 9621514 10078571 10102714 10333057 10588527 10482964 10084598 10966642 12355088 16959974