Names & Taxonomy
- Uniprot ID:
- P20823
- Entry Name:
- HNF1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
- Gene Names:
- HNF1A TCF1
- Gene Names Primary:
- HNF1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 631
- Sequence:
- MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSSQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
- Gene Ontology Go:
- cytoplasm
nucleus
protein complex
DNA binding
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
glucose homeostasis
glucose import
insulin secretion
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
renal glucose absorption
transcription from RNA polymerase II promoter - Gene Ontology Biological Process:
- glucose homeostasis
glucose import
insulin secretion
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription initiation from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
renal glucose absorption
transcription from RNA polymerase II promoter - Gene Ontology Molecular Function:
- DNA binding
protein dimerization activity
protein heterodimerization activity
protein homodimerization activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding - Gene Ontology Cellular Component:
- cytoplasm
nucleus
protein complex - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
DNA-binding
Diabetes mellitus
Disease mutation
Homeobox
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation - Interacts With:
- Q9Y463; Q92786