Names & Taxonomy
- Uniprot ID:
- P20815
- Entry Name:
- CP3A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450 HLp2) (Cytochrome P450-PCN3)
- Gene Names:
- CYP3A5
- Gene Names Primary:
- CYP3A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 502
- Sequence:
- MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB05773 DB00802 DB00404 DB06403 DB01118 DB00321 DB00381 DB00701 DB06605 DB00673 DB00278 DB01238 DB06413 DB06697 DB00637 DB01076 DB06626 DB00972 DB00394 DB08873 DB08870 DB00921 DB00490 DB06772 DB00201 DB00564 DB00446 DB00608 DB01114 DB01166 DB00501 DB00537 DB00604 DB01211 DB00575 DB00758 DB05239 DB00907 DB00318 DB08865 DB00531 DB00091 DB09102 DB00250 DB01254 DB00694 DB00705 DB01234 DB00514 DB00829 DB00343 DB00822 DB01248 DB08930 DB01184 DB01126 DB08899 DB00700 DB00530 DB00199 DB00783 DB00655 DB00593 DB00773 DB01023 DB00813 DB01216 DB00196 DB00472 DB00499 DB00588 DB01095 DB00176 DB00317 DB06730 DB00889 DB01218 DB00502 DB00741 DB06789 DB09053 DB01181 DB04946 DB00619 DB00224 DB00762 DB01167 DB01026 DB01259 DB00528 DB01227 DB00281 DB00678 DB00227 DB00333 DB00683 DB00834 DB00745 DB00688 DB00731 DB01149 DB00220 DB00238 DB00622 DB01115 DB00393 DB00401 DB01054 DB00717 DB01059 DB00540 DB00904 DB00842 DB00776 DB01062 DB00497 DB01229 DB01267 DB00738 DB08883 DB00780 DB01174 DB00252 DB01100 DB08901 DB00175 DB01058 DB00396 DB00571 DB01224 DB01103 DB00468 DB00863 DB00206 DB01045 DB01201 DB00734 DB00503 DB06228 DB01098 DB00938 DB01232 DB06335 DB00203 DB00641 DB00877 DB00398 DB00795 DB01268 DB00864 DB00675 DB00976 DB06287 DB00444 DB00624 DB01041 DB00656 DB00755 DB00897 DB01361 DB06267 DB00313 DB00862 DB00661 DB00541 DB00582 DB09068 DB00943 DB00962 DB00246 DB00425
- Gene Ontology Go:
- endoplasmic reticulum membrane
intracellular membrane-bounded organelle
aromatase activity
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
oxygen binding
alkaloid catabolic process
drug catabolic process
oxidative demethylation
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- alkaloid catabolic process
drug catabolic process
oxidative demethylation
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aromatase activity
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
oxygen binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
intracellular membrane-bounded organelle - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome