Names & Taxonomy

Uniprot ID:
P20648
Entry Name:
ATP4A_HUMAN
Status:
reviewed
Protein Names:
Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Gene Names:
ATP4A
Gene Names Primary:
ATP4A
Organism:
Homo sapiens (Human)

Structure

Length:
1035
Sequence:
MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
Catalytic Activity:
ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
Active Site:
ACT_SITE 387 387 4-aspartylphosphate intermediate.
Cross Reference Drug Bank:
DB00736 DB00448 DB00338 DB00213 DB01129
Gene Ontology Go:
extracellular space
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane
ATP binding
hydrogen:potassium-exchanging ATPase activity
magnesium ion binding
sodium:potassium-exchanging ATPase activity
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import
sodium ion export from cell
transmembrane transport
transport
Gene Ontology Biological Process:
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import
sodium ion export from cell
transmembrane transport
transport
Gene Ontology Molecular Function:
ATP binding
hydrogen:potassium-exchanging ATPase activity
magnesium ion binding
sodium:potassium-exchanging ATPase activity
Gene Ontology Cellular Component:
extracellular space
integral component of plasma membrane
intracellular membrane-bounded organelle
plasma membrane
Keywords:
ATP-binding
Cell membrane
Complete proteome
Hydrogen ion transport
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
2160952 2176086 15057824 3036582