Names & Taxonomy
- Uniprot ID:
- P20248
- Entry Name:
- CCNA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclin-A2 (Cyclin-A)
- Gene Names:
- CCNA2 CCN1 CCNA
- Gene Names Primary:
- CCNA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 432
- Sequence:
- MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
- Gene Ontology Go:
- cytoplasm
female pronucleus
Golgi apparatus
male pronucleus
nucleoplasm
nucleus
cell division
cellular response to cocaine
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to insulin-like growth factor stimulus
cellular response to leptin stimulus
cellular response to luteinizing hormone stimulus
cellular response to nitric oxide
cellular response to platelet-derived growth factor stimulus
cochlea development
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic G2 DNA damage checkpoint
mitotic nuclear division
organ regeneration
positive regulation of fibroblast proliferation
positive regulation of transcription, DNA-templated
Ras protein signal transduction
regulation of cyclin-dependent protein serine/threonine kinase activity
response to glucagon
viral process - Gene Ontology Biological Process:
- cell division
cellular response to cocaine
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to insulin-like growth factor stimulus
cellular response to leptin stimulus
cellular response to luteinizing hormone stimulus
cellular response to nitric oxide
cellular response to platelet-derived growth factor stimulus
cochlea development
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic G2 DNA damage checkpoint
mitotic nuclear division
organ regeneration
positive regulation of fibroblast proliferation
positive regulation of transcription, DNA-templated
Ras protein signal transduction
regulation of cyclin-dependent protein serine/threonine kinase activity
response to glucagon
viral process - Gene Ontology Cellular Component:
- cytoplasm
female pronucleus
Golgi apparatus
male pronucleus
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Cell cycle
Cell division
Complete proteome
Cyclin
Cytoplasm
Host-virus interaction
Mitosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation - Interacts With:
- P03070; P24941; P38936; P46527; Q96PU4