Names & Taxonomy
- Uniprot ID:
- P20061
- Entry Name:
- TCO1_HUMAN
- Status:
- reviewed
- Protein Names:
- Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein R) (Transcobalamin I) (TC I) (TCI)
- Gene Names:
- TCN1 TC1
- Gene Names Primary:
- TCN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 433
- Sequence:
- MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
- Cross Reference Drug Bank:
- DB00115 DB00200
- Gene Ontology Go:
- extracellular region
extracellular space
cobalamin binding
cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cobalamin metabolic process
cobalamin transport
cobalt ion transport
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- cobalamin binding
- Gene Ontology Cellular Component:
- extracellular region
extracellular space - Keywords:
- 3D-structure
Cobalt
Cobalt transport
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Polymorphism
Reference proteome
Secreted
Signal
Transport