Names & Taxonomy
- Uniprot ID:
- P20020
- Entry Name:
- AT2B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Plasma membrane calcium-transporting ATPase 1 (PMCA1) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 1) (Plasma membrane calcium pump isoform 1)
- Gene Names:
- ATP2B1 PMCA1
- Gene Names Primary:
- ATP2B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1258
- Sequence:
- MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQMDVVNAFQSGSSIQGALRRQPSIASQHHDVTNISTPTHIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Active Site:
- ACT_SITE 475 475 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
cytoplasmic side of plasma membrane
dendritic spine membrane
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
membrane raft
neuronal cell body membrane
nucleus
plasma membrane
ATP binding
calcium-transporting ATPase activity
metal ion binding
PDZ domain binding
aging
blood coagulation
brain development
calcium ion export
cardiac conduction
cellular calcium ion homeostasis
cellular response to corticosterone stimulus
cellular response to vitamin D
ion transmembrane transport
neural retina development
regulation of cardiac conduction
response to cold
transmembrane transport
transport - Gene Ontology Biological Process:
- aging
blood coagulation
brain development
calcium ion export
cardiac conduction
cellular calcium ion homeostasis
cellular response to corticosterone stimulus
cellular response to vitamin D
ion transmembrane transport
neural retina development
regulation of cardiac conduction
response to cold
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
calcium-transporting ATPase activity
metal ion binding
PDZ domain binding - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
cytoplasmic side of plasma membrane
dendritic spine membrane
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
membrane raft
neuronal cell body membrane
nucleus
plasma membrane - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Calcium
Calcium transport
Calmodulin-binding
Cell membrane
Complete proteome
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport