Names & Taxonomy
- Uniprot ID:
- P19971
- Entry Name:
- TYPH_HUMAN
- Status:
- reviewed
- Protein Names:
- Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)
- Gene Names:
- TYMP ECGF1
- Gene Names Primary:
- TYMP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 482
- Sequence:
- MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
- Proteomes:
- UP000005640
Function
- Function:
- May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
- Pathway:
- Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
- Catalytic Activity:
- Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
- Cross Reference Drug Bank:
- DB01101 DB00369 DB00322 DB00544 DB00432
- Gene Ontology Go:
- cytosol
phosphorylase activity
platelet-derived growth factor receptor binding
pyrimidine-nucleoside phosphorylase activity
thymidine phosphorylase activity
transferase activity, transferring pentosyl groups
angiogenesis
cell differentiation
chemotaxis
DNA replication
mitochondrial genome maintenance
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
pyrimidine nucleoside salvage
pyrimidine nucleotide metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- angiogenesis
cell differentiation
chemotaxis
DNA replication
mitochondrial genome maintenance
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
pyrimidine nucleoside salvage
pyrimidine nucleotide metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- phosphorylase activity
platelet-derived growth factor receptor binding
pyrimidine-nucleoside phosphorylase activity
thymidine phosphorylase activity
transferase activity, transferring pentosyl groups - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Angiogenesis
Chemotaxis
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disease mutation
Glycosyltransferase
Growth factor
Phosphoprotein
Polymorphism
Progressive external ophthalmoplegia
Reference proteome
Repeat
Transferase