Names & Taxonomy
- Uniprot ID:
- P19878
- Entry Name:
- NCF2_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)
- Gene Names:
- NCF2 NOXA2 P67PHOX
- Gene Names Primary:
- NCF2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 526
- Sequence:
- MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
- Cross Reference Drug Bank:
- DB00514
- Gene Ontology Go:
- acrosomal vesicle
cytoplasm
cytosol
NADPH oxidase complex
nucleolus
phagolysosome
electron carrier activity
protein C-terminus binding
superoxide-generating NADPH oxidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular defense response
innate immune response
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular defense response
innate immune response
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- electron carrier activity
protein C-terminus binding
superoxide-generating NADPH oxidase activity - Gene Ontology Cellular Component:
- acrosomal vesicle
cytoplasm
cytosol
NADPH oxidase complex
nucleolus
phagolysosome - Keywords:
- 3D-structure
Alternative splicing
Chronic granulomatous disease
Complete proteome
Cytoplasm
Disease mutation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3 domain
TPR repeat - Interacts With:
- P04899; P62873; Q08379; Q92845; P14598; Q15080; Q05655