Names & Taxonomy
- Uniprot ID:
- P19835
- Entry Name:
- CEL_HUMAN
- Status:
- reviewed
- Protein Names:
- Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Bucelipase) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase)
- Gene Names:
- CEL BAL
- Gene Names Primary:
- CEL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 753
- Sequence:
- MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
- Catalytic Activity:
- Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=24 uM for lipoyl-4-aminobenzoate
- Enzyme Regulation:
- ENZYME REGULATION: Activated by bile salts containing a 7-hydroxyl group.
- Active Site:
- ACT_SITE 214 214 Acyl-ester intermediate.
- Gene Ontology Go:
- cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
integral component of plasma membrane
synapse
acylglycerol lipase activity
catalytic activity
heparin binding
hydrolase activity
neurexin family protein binding
receptor activity
sterol esterase activity
triglyceride lipase activity
cholesterol catabolic process
fatty acid catabolic process
intestinal cholesterol absorption
intestinal lipid catabolic process
lipid digestion
lipid metabolic process
modulation of synaptic transmission
neuron cell-cell adhesion
pancreatic juice secretion
postsynaptic membrane assembly
presynaptic membrane assembly
protein esterification
small molecule metabolic process
synaptic vesicle endocytosis
triglyceride metabolic process - Gene Ontology Biological Process:
- cholesterol catabolic process
fatty acid catabolic process
intestinal cholesterol absorption
intestinal lipid catabolic process
lipid digestion
lipid metabolic process
modulation of synaptic transmission
neuron cell-cell adhesion
pancreatic juice secretion
postsynaptic membrane assembly
presynaptic membrane assembly
protein esterification
small molecule metabolic process
synaptic vesicle endocytosis
triglyceride metabolic process - Gene Ontology Molecular Function:
- acylglycerol lipase activity
catalytic activity
heparin binding
hydrolase activity
neurexin family protein binding
receptor activity
sterol esterase activity
triglyceride lipase activity - Gene Ontology Cellular Component:
- cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
integral component of plasma membrane
synapse - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Diabetes mellitus
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Reference proteome
Repeat
Secreted
Serine esterase
Signal