Names & Taxonomy
- Uniprot ID:
- P19801
- Entry Name:
- AOC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO)
- Gene Names:
- AOC1 ABP1 DAO1
- Gene Names Primary:
- AOC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 751
- Sequence:
- MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
- Catalytic Activity:
- Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by isoniazid, cimetidine, clonidine, pentamidine, berenil and pentamidine.
- Active Site:
- ACT_SITE 373 373 Proton acceptor.
- Cross Reference Drug Bank:
- DB00594
- Gene Ontology Go:
- bicellular tight junction
extracellular exosome
extracellular space
peroxisome
plasma membrane
calcium ion binding
copper ion binding
diamine oxidase activity
drug binding
heparin binding
histamine oxidase activity
methylputrescine oxidase activity
primary amine oxidase activity
propane-1,3-diamine oxidase activity
protein complex binding
protein homodimerization activity
quinone binding
receptor activity
zinc ion binding
amine metabolic process
cellular response to azide
cellular response to copper ion
cellular response to copper ion starvation
cellular response to heparin
cellular response to histamine
oxidation-reduction process
response to antibiotic
response to drug
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- amine metabolic process
cellular response to azide
cellular response to copper ion
cellular response to copper ion starvation
cellular response to heparin
cellular response to histamine
oxidation-reduction process
response to antibiotic
response to drug
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
copper ion binding
diamine oxidase activity
drug binding
heparin binding
histamine oxidase activity
methylputrescine oxidase activity
primary amine oxidase activity
propane-1,3-diamine oxidase activity
protein complex binding
protein homodimerization activity
quinone binding
receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- bicellular tight junction
extracellular exosome
extracellular space
peroxisome
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Copper
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparin-binding
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Secreted
Signal
TPQ