Names & Taxonomy
- Uniprot ID:
- P19634
- Entry Name:
- SL9A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
- Gene Names:
- SLC9A1 APNH1 NHE1
- Gene Names Primary:
- SLC9A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 815
- Sequence:
- MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane
- Intramembrane:
- INTRAMEM 382 402 Name=H10.
Function
- Function:
- Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
- Cross Reference Drug Bank:
- DB00594
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
cation-transporting ATPase complex
cell surface
cytoplasm
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
focal adhesion
integral component of membrane
integral component of plasma membrane
intercalated disc
lamellipodium
membrane raft
mitochondrion
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
T-tubule
calcium-dependent protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein binding, bridging
protein complex scaffold
protein phosphatase 2B binding
sodium:proton antiporter activity
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
solute:proton antiporter activity
carbohydrate metabolic process
cardiac muscle cell contraction
cardiac muscle cell differentiation
cell growth
cell migration
cellular response to acidic pH
cellular response to antibiotic
cellular response to electrical stimulus
cellular response to epinephrine stimulus
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to mechanical stimulus
cellular sodium ion homeostasis
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
hydrogen ion transmembrane transport
ion transport
maintenance of cell polarity
negative regulation of apoptotic process
neuron death
positive regulation of action potential
positive regulation of apoptotic process
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of calcium:sodium antiporter activity
positive regulation of cardiac muscle hypertrophy
positive regulation of cell growth
positive regulation of mitochondrial membrane permeability
positive regulation of NFAT protein import into nucleus
positive regulation of the force of heart contraction
positive regulation of transcription from RNA polymerase II promoter
protein oligomerization
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle contraction by calcium ion signaling
regulation of focal adhesion assembly
regulation of intracellular pH
regulation of pH
regulation of sensory perception of pain
regulation of stress fiber assembly
regulation of the force of heart contraction by cardiac conduction
response to acidic pH
response to drug
response to muscle stretch
small molecule metabolic process
sodium ion export
sodium ion import across plasma membrane
transmembrane transport - Gene Ontology Biological Process:
- carbohydrate metabolic process
cardiac muscle cell contraction
cardiac muscle cell differentiation
cell growth
cell migration
cellular response to acidic pH
cellular response to antibiotic
cellular response to electrical stimulus
cellular response to epinephrine stimulus
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to mechanical stimulus
cellular sodium ion homeostasis
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
hydrogen ion transmembrane transport
ion transport
maintenance of cell polarity
negative regulation of apoptotic process
neuron death
positive regulation of action potential
positive regulation of apoptotic process
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of calcium:sodium antiporter activity
positive regulation of cardiac muscle hypertrophy
positive regulation of cell growth
positive regulation of mitochondrial membrane permeability
positive regulation of NFAT protein import into nucleus
positive regulation of the force of heart contraction
positive regulation of transcription from RNA polymerase II promoter
protein oligomerization
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle contraction by calcium ion signaling
regulation of focal adhesion assembly
regulation of intracellular pH
regulation of pH
regulation of sensory perception of pain
regulation of stress fiber assembly
regulation of the force of heart contraction by cardiac conduction
response to acidic pH
response to drug
response to muscle stretch
small molecule metabolic process
sodium ion export
sodium ion import across plasma membrane
transmembrane transport - Gene Ontology Molecular Function:
- calcium-dependent protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein binding, bridging
protein complex scaffold
protein phosphatase 2B binding
sodium:proton antiporter activity
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
solute:proton antiporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
cation-transporting ATPase complex
cell surface
cytoplasm
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
focal adhesion
integral component of membrane
integral component of plasma membrane
intercalated disc
lamellipodium
membrane raft
mitochondrion
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
T-tubule - Keywords:
- 3D-structure
Alternative splicing
Antiport
Calmodulin-binding
Cell membrane
Complete proteome
Deafness
Disease mutation
Endoplasmic reticulum
Glycoprotein
Ion transport
Membrane
Neurodegeneration
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation