Names & Taxonomy

Uniprot ID:
P19634
Entry Name:
SL9A1_HUMAN
Status:
reviewed
Protein Names:
Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
Gene Names:
SLC9A1 APNH1 NHE1
Gene Names Primary:
SLC9A1
Organism:
Homo sapiens (Human)

Structure

Length:
815
Sequence:
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane
Intramembrane:
INTRAMEM 382 402 Name=H10.

Function

Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Cross Reference Drug Bank:
DB00594
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
cation-transporting ATPase complex
cell surface
cytoplasm
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
focal adhesion
integral component of membrane
integral component of plasma membrane
intercalated disc
lamellipodium
membrane raft
mitochondrion
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
T-tubule
calcium-dependent protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein binding, bridging
protein complex scaffold
protein phosphatase 2B binding
sodium:proton antiporter activity
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
solute:proton antiporter activity
carbohydrate metabolic process
cardiac muscle cell contraction
cardiac muscle cell differentiation
cell growth
cell migration
cellular response to acidic pH
cellular response to antibiotic
cellular response to electrical stimulus
cellular response to epinephrine stimulus
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to mechanical stimulus
cellular sodium ion homeostasis
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
hydrogen ion transmembrane transport
ion transport
maintenance of cell polarity
negative regulation of apoptotic process
neuron death
positive regulation of action potential
positive regulation of apoptotic process
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of calcium:sodium antiporter activity
positive regulation of cardiac muscle hypertrophy
positive regulation of cell growth
positive regulation of mitochondrial membrane permeability
positive regulation of NFAT protein import into nucleus
positive regulation of the force of heart contraction
positive regulation of transcription from RNA polymerase II promoter
protein oligomerization
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle contraction by calcium ion signaling
regulation of focal adhesion assembly
regulation of intracellular pH
regulation of pH
regulation of sensory perception of pain
regulation of stress fiber assembly
regulation of the force of heart contraction by cardiac conduction
response to acidic pH
response to drug
response to muscle stretch
small molecule metabolic process
sodium ion export
sodium ion import across plasma membrane
transmembrane transport
Gene Ontology Biological Process:
carbohydrate metabolic process
cardiac muscle cell contraction
cardiac muscle cell differentiation
cell growth
cell migration
cellular response to acidic pH
cellular response to antibiotic
cellular response to electrical stimulus
cellular response to epinephrine stimulus
cellular response to hypoxia
cellular response to insulin stimulus
cellular response to mechanical stimulus
cellular sodium ion homeostasis
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
hydrogen ion transmembrane transport
ion transport
maintenance of cell polarity
negative regulation of apoptotic process
neuron death
positive regulation of action potential
positive regulation of apoptotic process
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of calcium:sodium antiporter activity
positive regulation of cardiac muscle hypertrophy
positive regulation of cell growth
positive regulation of mitochondrial membrane permeability
positive regulation of NFAT protein import into nucleus
positive regulation of the force of heart contraction
positive regulation of transcription from RNA polymerase II promoter
protein oligomerization
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle contraction by calcium ion signaling
regulation of focal adhesion assembly
regulation of intracellular pH
regulation of pH
regulation of sensory perception of pain
regulation of stress fiber assembly
regulation of the force of heart contraction by cardiac conduction
response to acidic pH
response to drug
response to muscle stretch
small molecule metabolic process
sodium ion export
sodium ion import across plasma membrane
transmembrane transport
Gene Ontology Molecular Function:
calcium-dependent protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein binding, bridging
protein complex scaffold
protein phosphatase 2B binding
sodium:proton antiporter activity
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
solute:proton antiporter activity
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
cation-transporting ATPase complex
cell surface
cytoplasm
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
focal adhesion
integral component of membrane
integral component of plasma membrane
intercalated disc
lamellipodium
membrane raft
mitochondrion
nucleoplasm
perinuclear region of cytoplasm
plasma membrane
T-tubule
Keywords:
3D-structure
Alternative splicing
Antiport
Calmodulin-binding
Cell membrane
Complete proteome
Deafness
Disease mutation
Endoplasmic reticulum
Glycoprotein
Ion transport
Membrane
Neurodegeneration
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation

Publication

PubMed ID:
2536298 2154036 1712287 8283968 10913675 16710414 15489334 8068684 8967452 8901634 9688597 10713111 11696366 11350981 12226101 12809501 15035633 14680478 17525332 18088087 18669648 19690332 20068231 21392185 21406692 24275569 25205112 15677483 16511206 16710297 17050540