Names & Taxonomy

Uniprot ID:
P19367
Entry Name:
HXK1_HUMAN
Status:
reviewed
Protein Names:
Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I)
Gene Names:
HK1
Gene Names Primary:
HK1
Organism:
Homo sapiens (Human)

Structure

Length:
917
Sequence:
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding.

Function

Pathway:
Carbohydrate metabolism; hexose metabolism.
Catalytic Activity:
ATP + D-hexose = ADP + D-hexose 6-phosphate.
Enzyme Regulation:
ENZYME REGULATION: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.
Gene Ontology Go:
cytosol
membrane raft
mitochondrial outer membrane
mitochondrion
sperm principal piece
ATP binding
fructokinase activity
glucokinase activity
glucose binding
hexokinase activity
mannokinase activity
canonical glycolysis
carbohydrate metabolic process
cellular glucose homeostasis
establishment of protein localization to mitochondrion
glucose metabolic process
glucose transport
glycolytic process
hexose transport
maintenance of protein location in mitochondrion
small molecule metabolic process
transmembrane transport
Gene Ontology Biological Process:
canonical glycolysis
carbohydrate metabolic process
cellular glucose homeostasis
establishment of protein localization to mitochondrion
glucose metabolic process
glucose transport
glycolytic process
hexose transport
maintenance of protein location in mitochondrion
small molecule metabolic process
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
fructokinase activity
glucokinase activity
glucose binding
hexokinase activity
mannokinase activity
Gene Ontology Cellular Component:
cytosol
membrane raft
mitochondrial outer membrane
mitochondrion
sperm principal piece
Keywords:
3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Charcot-Marie-Tooth disease
Complete proteome
Direct protein sequencing
Disease mutation
Glycolysis
Kinase
Membrane
Mitochondrion
Mitochondrion outer membrane
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transferase
Interacts With:
P21796

Publication

PubMed ID:
3207429 9531504 15164054 15489334 10978502 1985912 1637300 9028305 8706938 19413330 19536174 21269460 22304920 25944712 9493266 9735292 10574795 10686099 7655856 12393545