Names & Taxonomy
- Uniprot ID:
- P19367
- Entry Name:
- HXK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I)
- Gene Names:
- HK1
- Gene Names Primary:
- HK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 917
- Sequence:
- MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding.
Function
- Pathway:
- Carbohydrate metabolism; hexose metabolism.
- Catalytic Activity:
- ATP + D-hexose = ADP + D-hexose 6-phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.
- Gene Ontology Go:
- cytosol
membrane raft
mitochondrial outer membrane
mitochondrion
sperm principal piece
ATP binding
fructokinase activity
glucokinase activity
glucose binding
hexokinase activity
mannokinase activity
canonical glycolysis
carbohydrate metabolic process
cellular glucose homeostasis
establishment of protein localization to mitochondrion
glucose metabolic process
glucose transport
glycolytic process
hexose transport
maintenance of protein location in mitochondrion
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
cellular glucose homeostasis
establishment of protein localization to mitochondrion
glucose metabolic process
glucose transport
glycolytic process
hexose transport
maintenance of protein location in mitochondrion
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
fructokinase activity
glucokinase activity
glucose binding
hexokinase activity
mannokinase activity - Gene Ontology Cellular Component:
- cytosol
membrane raft
mitochondrial outer membrane
mitochondrion
sperm principal piece - Keywords:
- 3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Charcot-Marie-Tooth disease
Complete proteome
Direct protein sequencing
Disease mutation
Glycolysis
Kinase
Membrane
Mitochondrion
Mitochondrion outer membrane
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transferase - Interacts With:
- P21796