Names & Taxonomy

Uniprot ID:
P19113
Entry Name:
DCHS_HUMAN
Status:
reviewed
Protein Names:
Histidine decarboxylase (HDC) (EC 4.1.1.22)
Gene Names:
HDC
Gene Names Primary:
HDC
Organism:
Homo sapiens (Human)

Structure

Length:
662
Sequence:
MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV
Proteomes:
UP000005640

Function

Function:
Catalyzes the biosynthesis of histamine from histidine.
Pathway:
Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.
Catalytic Activity:
L-histidine = histamine + CO(2).
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.1 mM for histidine
Cross Reference Drug Bank:
DB00117
Gene Ontology Go:
cytosol
histidine decarboxylase activity
pyridoxal phosphate binding
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
histamine biosynthetic process
histidine catabolic process
histidine metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
histamine biosynthetic process
histidine catabolic process
histidine metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
histidine decarboxylase activity
pyridoxal phosphate binding
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Alternative splicing
Catecholamine biosynthesis
Complete proteome
Decarboxylase
Lyase
Polymorphism
Pyridoxal phosphate
Reference proteome
Interacts With:
Q4ZH49; Q86UW9

Publication

PubMed ID:
2216786 1768863 1425659 8288622 16572171 15489334 22767596 16959974