Names & Taxonomy
- Uniprot ID:
- P19113
- Entry Name:
- DCHS_HUMAN
- Status:
- reviewed
- Protein Names:
- Histidine decarboxylase (HDC) (EC 4.1.1.22)
- Gene Names:
- HDC
- Gene Names Primary:
- HDC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 662
- Sequence:
- MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the biosynthesis of histamine from histidine.
- Pathway:
- Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.
- Catalytic Activity:
- L-histidine = histamine + CO(2).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.1 mM for histidine
- Cross Reference Drug Bank:
- DB00117
- Gene Ontology Go:
- cytosol
histidine decarboxylase activity
pyridoxal phosphate binding
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
histamine biosynthetic process
histidine catabolic process
histidine metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- catecholamine biosynthetic process
cellular nitrogen compound metabolic process
histamine biosynthetic process
histidine catabolic process
histidine metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- histidine decarboxylase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Catecholamine biosynthesis
Complete proteome
Decarboxylase
Lyase
Polymorphism
Pyridoxal phosphate
Reference proteome - Interacts With:
- Q4ZH49; Q86UW9