Names & Taxonomy
- Uniprot ID:
- P19022
- Entry Name:
- CADH2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
- Gene Names:
- CDH2 CDHN NCAD
- Gene Names Primary:
- CDH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 906
- Sequence:
- MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
catenin complex
cell-cell adherens junction
cell-cell junction
cytoplasm
extracellular exosome
fascia adherens
focal adhesion
integral component of membrane
intercalated disc
lamellipodium
plasma membrane
plasma membrane raft
synapse
alpha-catenin binding
beta-catenin binding
calcium ion binding
gamma-catenin binding
adherens junction organization
blood vessel morphogenesis
brain morphogenesis
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion
cell junction assembly
cell migration
cell-cell adhesion mediated by cadherin
cell-cell junction organization
cerebral cortex development
establishment of protein localization to plasma membrane
glial cell differentiation
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homeostasis of number of cells
homophilic cell adhesion via plasma membrane adhesion molecules
muscle cell differentiation
negative regulation of canonical Wnt signaling pathway
neuroepithelial cell differentiation
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
positive regulation of MAPK cascade
positive regulation of muscle cell differentiation
positive regulation of synaptic vesicle clustering
protein heterooligomerization
radial glial cell differentiation
regulation of axonogenesis
regulation of myelination
regulation of oligodendrocyte progenitor proliferation
regulation of postsynaptic density protein 95 clustering
regulation of Rho protein signal transduction
striated muscle cell differentiation - Gene Ontology Biological Process:
- adherens junction organization
blood vessel morphogenesis
brain morphogenesis
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion
cell-cell adhesion mediated by cadherin
cell-cell junction organization
cell junction assembly
cell migration
cerebral cortex development
establishment of protein localization to plasma membrane
glial cell differentiation
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homeostasis of number of cells
homophilic cell adhesion via plasma membrane adhesion molecules
muscle cell differentiation
negative regulation of canonical Wnt signaling pathway
neuroepithelial cell differentiation
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
positive regulation of MAPK cascade
positive regulation of muscle cell differentiation
positive regulation of synaptic vesicle clustering
protein heterooligomerization
radial glial cell differentiation
regulation of axonogenesis
regulation of myelination
regulation of oligodendrocyte progenitor proliferation
regulation of postsynaptic density protein 95 clustering
regulation of Rho protein signal transduction
striated muscle cell differentiation - Gene Ontology Molecular Function:
- alpha-catenin binding
beta-catenin binding
calcium ion binding
gamma-catenin binding - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
catenin complex
cell-cell adherens junction
cell-cell junction
cytoplasm
extracellular exosome
fascia adherens
focal adhesion
integral component of membrane
intercalated disc
lamellipodium
plasma membrane
plasma membrane raft
synapse - Keywords:
- Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P35222