Names & Taxonomy
- Uniprot ID:
- P18507
- Entry Name:
- GBRG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2)
- Gene Names:
- GABRG2
- Gene Names Primary:
- GABRG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 467
- Sequence:
- MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane
Function
- Function:
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
- Cross Reference Drug Bank:
- DB00659 DB00546 DB00404 DB00543 DB01558 DB00237 DB00241 DB00475 DB01594 DB00349 DB01068 DB00628 DB01559 DB01189 DB00829 DB00228 DB01049 DB01215 DB00402 DB00189 DB00292 DB01567 DB01205 DB00690 DB01381 DB01437 DB00801 DB01159 DB00753 DB00186 DB00371 DB01028 DB01107 DB00683 DB01595 DB00334 DB00842 DB00312 DB01588 DB00794 DB00818 DB01589 DB01236 DB00306 DB00231 DB00273 DB00897
- Gene Ontology Go:
- axon
cell junction
chloride channel complex
cytoplasm
dendrite membrane
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
benzodiazepine receptor activity
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
adult behavior
cellular response to histamine
chemical synaptic transmission, postsynaptic
chloride transmembrane transport
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
post-embryonic development
synaptic transmission
synaptic transmission, GABAergic
transmembrane transport
transport - Gene Ontology Biological Process:
- adult behavior
cellular response to histamine
chemical synaptic transmission, postsynaptic
chloride transmembrane transport
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
post-embryonic development
synaptic transmission
synaptic transmission, GABAergic
transmembrane transport
transport - Gene Ontology Molecular Function:
- benzodiazepine receptor activity
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity - Gene Ontology Cellular Component:
- axon
cell junction
chloride channel complex
cytoplasm
dendrite membrane
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Lipoprotein
Membrane
Palmitate
Postsynaptic cell membrane
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport