Names & Taxonomy

Uniprot ID:
P18440
Entry Name:
ARY1_HUMAN
Status:
reviewed
Protein Names:
Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1)
Gene Names:
NAT1 AAC1
Gene Names Primary:
NAT1
Organism:
Homo sapiens (Human)

Structure

Length:
290
Sequence:
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Catalytic Activity:
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Active Site:
ACT_SITE 68 68 Acyl-thioester intermediate.; ACT_SITE 107 107; ACT_SITE 122 122
Cross Reference Drug Bank:
DB01015
Gene Ontology Go:
cytosol
arylamine N-acetyltransferase activity
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
arylamine N-acetyltransferase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acetylation
Acyltransferase
Complete proteome
Cytoplasm
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
2340091 1968463 8442668 9168895 9511183 10862520 16416399 14702039 15489334 1676262 9173883 22814378 17656365 7585580 9511182 9682272