Names & Taxonomy
- Uniprot ID:
- P18440
- Entry Name:
- ARY1_HUMAN
- Status:
- reviewed
- Protein Names:
- Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1)
- Gene Names:
- NAT1 AAC1
- Gene Names Primary:
- NAT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 290
- Sequence:
- MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
- Catalytic Activity:
- Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
- Active Site:
- ACT_SITE 68 68 Acyl-thioester intermediate.; ACT_SITE 107 107; ACT_SITE 122 122
- Cross Reference Drug Bank:
- DB01015
- Gene Ontology Go:
- cytosol
arylamine N-acetyltransferase activity
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- arylamine N-acetyltransferase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Acyltransferase
Complete proteome
Cytoplasm
Polymorphism
Reference proteome
Transferase