Names & Taxonomy

Uniprot ID:
P18089
Entry Name:
ADA2B_HUMAN
Status:
reviewed
Protein Names:
Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)
Gene Names:
ADRA2B ADRA2L1 ADRA2RL1
Gene Names Primary:
ADRA2B
Organism:
Homo sapiens (Human)

Structure

Length:
447
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Cross Reference Drug Bank:
DB00543 DB00182 DB00714 DB00964 DB01238 DB06216 DB00217 DB00484 DB01200 DB00248 DB01136 DB00477 DB00575 DB00363 DB01151 DB01142 DB04855 DB06262 DB01363 DB00668 DB01049 DB00696 DB00292 DB00800 DB00629 DB01018 DB00589 DB00408 DB00934 DB01365 DB01577 DB01403 DB06148 DB00368 DB00540 DB00334 DB00935 DB01267 DB01186 DB00925 DB00413 DB00457 DB01224 DB00734 DB00268 DB05271 DB00697 DB00797 DB00726 DB06694 DB01392 DB00246
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
alpha2-adrenergic receptor activity
epinephrine binding
activation of MAPK activity by adrenergic receptor signaling pathway
activation of protein kinase B activity
adenylate cyclase-activating adrenergic receptor signaling pathway
blood coagulation
cell-cell signaling
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of epinephrine secretion
negative regulation of norepinephrine secretion
platelet activation
positive regulation of neuron differentiation
regulation of smooth muscle contraction
regulation of vasoconstriction
Gene Ontology Biological Process:
activation of MAPK activity by adrenergic receptor signaling pathway
activation of protein kinase B activity
adenylate cyclase-activating adrenergic receptor signaling pathway
blood coagulation
cell-cell signaling
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of epinephrine secretion
negative regulation of norepinephrine secretion
platelet activation
positive regulation of neuron differentiation
regulation of smooth muscle contraction
regulation of vasoconstriction
Gene Ontology Molecular Function:
alpha2-adrenergic receptor activity
epinephrine binding
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Disulfide bond
Epilepsy
G-protein coupled receptor
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Interacts With:
Q9ULW5

Publication

PubMed ID:
2164221 2172775 11056163 15037199 15815621 2173582 23105096 24114805