Names & Taxonomy
- Uniprot ID:
- P17936
- Entry Name:
- IBP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
- Gene Names:
- IGFBP3 IBP3
- Gene Names Primary:
- IGFBP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 291
- Sequence:
- MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
- Cross Reference Drug Bank:
- DB01277
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
insulin-like growth factor binding protein complex
insulin-like growth factor ternary complex
nucleus
fibronectin binding
insulin-like growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
metal ion binding
protein tyrosine phosphatase activator activity
apoptotic process
cellular protein metabolic process
negative regulation of cell proliferation
negative regulation of protein phosphorylation
negative regulation of signal transduction
negative regulation of smooth muscle cell migration
negative regulation of smooth muscle cell proliferation
osteoblast differentiation
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of myoblast differentiation
protein phosphorylation
regulation of cell growth
regulation of glucose metabolic process
regulation of insulin-like growth factor receptor signaling pathway
type B pancreatic cell proliferation - Gene Ontology Biological Process:
- apoptotic process
cellular protein metabolic process
negative regulation of cell proliferation
negative regulation of protein phosphorylation
negative regulation of signal transduction
negative regulation of smooth muscle cell migration
negative regulation of smooth muscle cell proliferation
osteoblast differentiation
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of myoblast differentiation
protein phosphorylation
regulation of cell growth
regulation of glucose metabolic process
regulation of insulin-like growth factor receptor signaling pathway
type B pancreatic cell proliferation - Gene Ontology Molecular Function:
- fibronectin binding
insulin-like growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
metal ion binding
protein tyrosine phosphatase activator activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
insulin-like growth factor binding protein complex
insulin-like growth factor ternary complex
nucleus - Keywords:
- Alternative splicing
Apoptosis
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- P00533; P78527