Names & Taxonomy
- Uniprot ID:
- P17844
- Entry Name:
- DDX5_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
- Gene Names:
- DDX5 G17P1 HELR HLR1
- Gene Names Primary:
- DDX5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 614
- Sequence:
- MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus
Function
- Function:
- Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Gene Ontology Go:
- catalytic step 2 spliceosome
extracellular exosome
intracellular ribonucleoprotein complex
membrane
nucleolus
nucleoplasm
nucleus
androgen receptor binding
ATP binding
ATP-dependent RNA helicase activity
estrogen receptor binding
poly(A) RNA binding
pre-mRNA binding
RNA helicase activity
transcription coactivator activity
cell growth
intrinsic apoptotic signaling pathway by p53 class mediator
mRNA splicing, via spliceosome
mRNA transcription
negative regulation of transcription from RNA polymerase II promoter
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
regulation of androgen receptor signaling pathway
regulation of osteoblast differentiation
regulation of skeletal muscle cell differentiation
regulation of viral genome replication
rhythmic process
RNA secondary structure unwinding - Gene Ontology Biological Process:
- cell growth
intrinsic apoptotic signaling pathway by p53 class mediator
mRNA splicing, via spliceosome
mRNA transcription
negative regulation of transcription from RNA polymerase II promoter
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
regulation of androgen receptor signaling pathway
regulation of osteoblast differentiation
regulation of skeletal muscle cell differentiation
regulation of viral genome replication
rhythmic process
RNA secondary structure unwinding - Gene Ontology Molecular Function:
- androgen receptor binding
ATP binding
ATP-dependent RNA helicase activity
estrogen receptor binding
poly(A) RNA binding
pre-mRNA binding
RNA helicase activity
transcription coactivator activity - Gene Ontology Cellular Component:
- catalytic step 2 spliceosome
extracellular exosome
intracellular ribonucleoprotein complex
membrane
nucleolus
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Biological rhythms
Complete proteome
Helicase
Hydrolase
Isopeptide bond
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Spliceosome
Transcription
Transcription regulation
Ubl conjugation
mRNA processing
mRNA splicing - Interacts With:
- P27958; P29991; Q12873; P45481; Q92841; Q8AZK7; Q09472; P03372; Q01780; P22087; Q13547; O95983; P10085; O94916; B4URF5; P24928; Q08775-3; Q15637; P04637; P04637-1; P04637-7
Publication
- PubMed ID:
- 2349099 1996094 10648785 14702039 19054851 16625196 15489334 2451786 10409727 10837141 11250900 11991638 12595555 12527917 15298701 15660129 15592455 17011493 17932509 17369852 18829551 17960593 18669648 19718048 19608861 19995069 20068231 21269460 21343338 21406692 25218447 25772364 25755297 25944712 20941364