Names & Taxonomy
- Uniprot ID:
- P17707
- Entry Name:
- DCAM_HUMAN
- Status:
- reviewed
- Protein Names:
- S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]
- Gene Names:
- AMD1 AMD
- Gene Names Primary:
- AMD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 334
- Sequence:
- MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
- Proteomes:
- UP000005640
Function
- Function:
- Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity).
- Pathway:
- Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
- Catalytic Activity:
- S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2).
- Cofactor:
- COFACTOR: Name=pyruvate; Xref=ChEBI:CHEBI:15361; ; Note=Binds 1 pyruvoyl group covalently per subunit.;
- Enzyme Regulation:
- ENZYME REGULATION: Both proenzyme processing and catalytic activity are stimulated by putrescine. Catalytic activity is inhibited by iodoacetic acid.
- Active Site:
- ACT_SITE 8 8; ACT_SITE 11 11; ACT_SITE 68 68 Schiff-base intermediate with substrate; via pyruvic acid.
- Cross Reference Drug Bank:
- DB00118 DB03754
- Gene Ontology Go:
- cytosol
adenosylmethionine decarboxylase activity
putrescine binding
cellular nitrogen compound metabolic process
polyamine metabolic process
S-adenosylmethioninamine biosynthetic process
S-adenosylmethionine metabolic process
small molecule metabolic process
spermidine biosynthetic process
spermine biosynthetic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
polyamine metabolic process
S-adenosylmethioninamine biosynthetic process
S-adenosylmethionine metabolic process
small molecule metabolic process
spermidine biosynthetic process
spermine biosynthetic process - Gene Ontology Molecular Function:
- adenosylmethionine decarboxylase activity
putrescine binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Autocatalytic cleavage
Complete proteome
Decarboxylase
Direct protein sequencing
Lyase
Phosphoprotein
Polyamine biosynthesis
Pyruvate
Reference proteome
S-adenosyl-L-methionine
Schiff base
Spermidine biosynthesis
Zymogen