Names & Taxonomy
- Uniprot ID:
- P17600
- Entry Name:
- SYN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Synapsin-1 (Brain protein 4.1) (Synapsin I)
- Gene Names:
- SYN1
- Gene Names Primary:
- SYN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 705
- Sequence:
- MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse. Golgi apparatus
Function
- Function:
- Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
- Gene Ontology Go:
- cell junction
cytosol
dendrite
Golgi apparatus
myelin sheath
postsynaptic density
presynaptic active zone
synaptic vesicle
synaptic vesicle membrane
synaptonemal complex
terminal bouton
ATP binding
catalytic activity
protein kinase binding
transporter activity
neurotransmitter secretion
regulation of neurotransmitter secretion
regulation of synaptic vesicle exocytosis
synaptic transmission - Gene Ontology Biological Process:
- neurotransmitter secretion
regulation of neurotransmitter secretion
regulation of synaptic vesicle exocytosis
synaptic transmission - Gene Ontology Molecular Function:
- ATP binding
catalytic activity
protein kinase binding
transporter activity - Gene Ontology Cellular Component:
- cell junction
cytosol
dendrite
Golgi apparatus
myelin sheath
postsynaptic density
presynaptic active zone
synaptic vesicle
synaptic vesicle membrane
synaptonemal complex
terminal bouton - Keywords:
- Actin-binding
Alternative splicing
Cell junction
Complete proteome
Epilepsy
Glycoprotein
Golgi apparatus
Phosphoprotein
Reference proteome
Repeat
Synapse - Interacts With:
- P37840