Names & Taxonomy

Uniprot ID:
P17405
Entry Name:
ASM_HUMAN
Status:
reviewed
Protein Names:
Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase)
Gene Names:
SMPD1 ASM
Gene Names Primary:
SMPD1
Organism:
Homo sapiens (Human)

Structure

Length:
629
Sequence:
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome

Function

Function:
Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
Catalytic Activity:
Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Cross Reference Drug Bank:
DB00381 DB00477 DB01151
Gene Ontology Go:
endosome
extracellular exosome
extracellular space
lamellar body
lysosomal lumen
lysosome
plasma membrane
acid sphingomyelin phosphodiesterase activity
hydrolase activity, acting on glycosyl bonds
sphingomyelin phosphodiesterase activity
zinc ion binding
ceramide biosynthetic process
glycosphingolipid metabolic process
negative regulation of MAP kinase activity
nervous system development
positive regulation of apoptotic process
positive regulation of protein dephosphorylation
response to cocaine
response to drug
signal transduction
small molecule metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process
sphingomyelin metabolic process
termination of signal transduction
Gene Ontology Biological Process:
ceramide biosynthetic process
glycosphingolipid metabolic process
negative regulation of MAP kinase activity
nervous system development
positive regulation of apoptotic process
positive regulation of protein dephosphorylation
response to cocaine
response to drug
signal transduction
small molecule metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process
sphingomyelin metabolic process
termination of signal transduction
Gene Ontology Molecular Function:
acid sphingomyelin phosphodiesterase activity
hydrolase activity, acting on glycosyl bonds
sphingomyelin phosphodiesterase activity
zinc ion binding
Gene Ontology Cellular Component:
endosome
extracellular exosome
extracellular space
lamellar body
lysosomal lumen
lysosome
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Metal-binding
Neurodegeneration
Niemann-Pick disease
Reference proteome
Secreted
Signal
Zinc
Interacts With:
P55210

Publication

PubMed ID:
1840600 1292508 1740330 8407868 14702039 16554811 2555181 8702487 9030779 12631268 18088425 1718266 2023926 1885770 1391960 1301192 1618760 8051942 8680412 8693491 8664904 9266408 12369017 12556236 15221801 15241805 16010684 15877209 16472269 18815062 19050888 19405096 20386867 21621718 22613662 23430884 22818240 23252888 23430512 26499107 26084044