Names & Taxonomy

Uniprot ID:
P17213
Entry Name:
BPI_HUMAN
Status:
reviewed
Protein Names:
Bactericidal permeability-increasing protein (BPI) (CAP 57)
Gene Names:
BPI
Gene Names Primary:
BPI
Organism:
Homo sapiens (Human)

Structure

Length:
487
Sequence:
MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Gene Ontology Go:
cytoplasm
extracellular exosome
extracellular space
integral component of plasma membrane
lipopolysaccharide binding
defense response to Gram-negative bacterium
immune response
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of macrophage activation
negative regulation of tumor necrosis factor production
Gene Ontology Biological Process:
defense response to Gram-negative bacterium
immune response
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of macrophage activation
negative regulation of tumor necrosis factor production
Gene Ontology Molecular Function:
lipopolysaccharide binding
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
extracellular space
integral component of plasma membrane
Keywords:
3D-structure
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
2722846 7517398 14702039 11780052 15489334 1937776 2501794 3667613 8812832 9188532 10843855