Names & Taxonomy
- Uniprot ID:
- P17213
- Entry Name:
- BPI_HUMAN
- Status:
- reviewed
- Protein Names:
- Bactericidal permeability-increasing protein (BPI) (CAP 57)
- Gene Names:
- BPI
- Gene Names Primary:
- BPI
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 487
- Sequence:
- MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
extracellular space
integral component of plasma membrane
lipopolysaccharide binding
defense response to Gram-negative bacterium
immune response
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of macrophage activation
negative regulation of tumor necrosis factor production - Gene Ontology Biological Process:
- defense response to Gram-negative bacterium
immune response
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of macrophage activation
negative regulation of tumor necrosis factor production - Gene Ontology Molecular Function:
- lipopolysaccharide binding
- Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
extracellular space
integral component of plasma membrane - Keywords:
- 3D-structure
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Secreted
Signal