Names & Taxonomy

Uniprot ID:
P16870
Entry Name:
CBPE_HUMAN
Status:
reviewed
Protein Names:
Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
Gene Names:
CPE
Gene Names Primary:
CPE
Organism:
Homo sapiens (Human)

Structure

Length:
476
Sequence:
MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane

Function

Function:
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Catalytic Activity:
Release of C-terminal arginine or lysine residues from polypeptides.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 342 342 Proton donor/acceptor.
Cross Reference Drug Bank:
DB00030
Gene Ontology Go:
extracellular exosome
extracellular space
Golgi apparatus
neuronal cell body
nucleus
plasma membrane
secretory granule
secretory granule membrane
synaptic membrane
transport vesicle membrane
carboxypeptidase activity
cell adhesion molecule binding
metallocarboxypeptidase activity
neurexin family protein binding
serine-type carboxypeptidase activity
zinc ion binding
cardiac left ventricle morphogenesis
cellular protein metabolic process
cellular protein modification process
insulin processing
metabolic process
neuropeptide signaling pathway
protein localization to membrane
Wnt signaling pathway
Gene Ontology Biological Process:
cardiac left ventricle morphogenesis
cellular protein metabolic process
cellular protein modification process
insulin processing
metabolic process
neuropeptide signaling pathway
protein localization to membrane
Wnt signaling pathway
Gene Ontology Molecular Function:
carboxypeptidase activity
cell adhesion molecule binding
metallocarboxypeptidase activity
neurexin family protein binding
serine-type carboxypeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular exosome
extracellular space
Golgi apparatus
neuronal cell body
nucleus
plasma membrane
secretory granule
secretory granule membrane
synaptic membrane
transport vesicle membrane
Keywords:
Alternative splicing
Carboxypeptidase
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Nucleus
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen
Interacts With:
Q13131

Publication

PubMed ID:
2334405 9662053 14702039 15489334 21285511 16959974