Names & Taxonomy
- Uniprot ID:
- P16870
- Entry Name:
- CBPE_HUMAN
- Status:
- reviewed
- Protein Names:
- Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
- Gene Names:
- CPE
- Gene Names Primary:
- CPE
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 476
- Sequence:
- MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane
Function
- Function:
- Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
- Catalytic Activity:
- Release of C-terminal arginine or lysine residues from polypeptides.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 342 342 Proton donor/acceptor.
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- extracellular exosome
extracellular space
Golgi apparatus
neuronal cell body
nucleus
plasma membrane
secretory granule
secretory granule membrane
synaptic membrane
transport vesicle membrane
carboxypeptidase activity
cell adhesion molecule binding
metallocarboxypeptidase activity
neurexin family protein binding
serine-type carboxypeptidase activity
zinc ion binding
cardiac left ventricle morphogenesis
cellular protein metabolic process
cellular protein modification process
insulin processing
metabolic process
neuropeptide signaling pathway
protein localization to membrane
Wnt signaling pathway - Gene Ontology Biological Process:
- cardiac left ventricle morphogenesis
cellular protein metabolic process
cellular protein modification process
insulin processing
metabolic process
neuropeptide signaling pathway
protein localization to membrane
Wnt signaling pathway - Gene Ontology Molecular Function:
- carboxypeptidase activity
cell adhesion molecule binding
metallocarboxypeptidase activity
neurexin family protein binding
serine-type carboxypeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular space
Golgi apparatus
neuronal cell body
nucleus
plasma membrane
secretory granule
secretory granule membrane
synaptic membrane
transport vesicle membrane - Keywords:
- Alternative splicing
Carboxypeptidase
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Nucleus
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen - Interacts With:
- Q13131