Names & Taxonomy
- Uniprot ID:
- P16410
- Entry Name:
- CTLA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)
- Gene Names:
- CTLA4 CD152
- Gene Names Primary:
- CTLA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 223
- Sequence:
- MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLLTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
- Cross Reference Drug Bank:
- DB06186
- Gene Ontology Go:
- clathrin-coated endocytic vesicle
external side of plasma membrane
Golgi apparatus
integral component of plasma membrane
perinuclear region of cytoplasm
plasma membrane
adaptive immune response
B cell receptor signaling pathway
cellular response to DNA damage stimulus
immune response
negative regulation of B cell proliferation
negative regulation of regulatory T cell differentiation
positive regulation of apoptotic process
T cell costimulation - Gene Ontology Biological Process:
- adaptive immune response
B cell receptor signaling pathway
cellular response to DNA damage stimulus
immune response
negative regulation of B cell proliferation
negative regulation of regulatory T cell differentiation
positive regulation of apoptotic process
T cell costimulation - Gene Ontology Cellular Component:
- clathrin-coated endocytic vesicle
external side of plasma membrane
Golgi apparatus
integral component of plasma membrane
perinuclear region of cytoplasm
plasma membrane - Keywords:
- 3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Complete proteome
Diabetes mellitus
Disease mutation
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Membrane
Pharmaceutical
Phosphoprotein
Polymorphism
Reference proteome
Signal
Systemic lupus erythematosus
Transmembrane
Transmembrane helix - Interacts With:
- P33681; P42081; P27986