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Names & Taxonomy

Uniprot ID:: P16234
Entry Name:: PGFRA_HUMAN
Status:: reviewed
Protein Names:: Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene Names:: PDGFRA PDGFR2 RHEPDGFRA
Gene Names Primary:: PDGFRA
Organism:: Homo sapiens (Human)

Structure

Length:: 1089
Sequence:: MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cell membrane

Function

Function:: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Catalytic Activity:: ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Enzyme Regulation:: ENZYME REGULATION: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and sorafenib.
Active Site:: ACT_SITE 818 818 Proton acceptor.
Cross Reference Drug Bank:: DB00102 DB00619 DB06589 DB08901 DB08896 DB01268
Gene Ontology Go:: cytoplasm
integral component of plasma membrane
intrinsic component of plasma membrane
membrane
nucleus
plasma membrane
protein complex
ATP binding
platelet-derived growth factor alpha-receptor activity
platelet-derived growth factor binding
platelet-derived growth factor receptor binding
protein homodimerization activity
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor binding
vascular endothelial growth factor-activated receptor activity
activation of MAPKK activity
axon guidance
cardiac myofibril assembly
cell activation
cell chemotaxis
cellular response to reactive oxygen species
embryonic cranial skeleton morphogenesis
embryonic digestive tract morphogenesis
embryonic skeletal system morphogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
luteinization
MAPK cascade
metanephric glomerular capillary formation
negative regulation of platelet activation
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
platelet aggregation
platelet-derived growth factor receptor signaling pathway
platelet-derived growth factor receptor-alpha signaling pathway
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of DNA replication
positive regulation of ERK1 and ERK2 cascade
positive regulation of fibroblast proliferation
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase C activity
protein autophosphorylation
Ras protein signal transduction
regulation of actin cytoskeleton reorganization
regulation of chemotaxis
regulation of mesenchymal stem cell differentiation
retina vasculature development in camera-type eye
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process
wound healing
Gene Ontology Biological Process:: activation of MAPKK activity
axon guidance
cardiac myofibril assembly
cell activation
cell chemotaxis
cellular response to reactive oxygen species
embryonic cranial skeleton morphogenesis
embryonic digestive tract morphogenesis
embryonic skeletal system morphogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
luteinization
MAPK cascade
metanephric glomerular capillary formation
negative regulation of platelet activation
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
platelet aggregation
platelet-derived growth factor receptor-alpha signaling pathway
platelet-derived growth factor receptor signaling pathway
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of DNA replication
positive regulation of ERK1 and ERK2 cascade
positive regulation of fibroblast proliferation
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase C activity
protein autophosphorylation
Ras protein signal transduction
regulation of actin cytoskeleton reorganization
regulation of chemotaxis
regulation of mesenchymal stem cell differentiation
retina vasculature development in camera-type eye
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process
wound healing
Gene Ontology Molecular Function:: ATP binding
platelet-derived growth factor alpha-receptor activity
platelet-derived growth factor binding
platelet-derived growth factor receptor binding
protein homodimerization activity
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
vascular endothelial growth factor binding
Gene Ontology Cellular Component:: cytoplasm
integral component of plasma membrane
intrinsic component of plasma membrane
membrane
nucleus
plasma membrane
protein complex
Keywords:: 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Chemotaxis
Complete proteome
Developmental protein
Disulfide bond
Glycoprotein
Host-virus interaction
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation
Interacts With:: Q8N6L0; P46108; P46109; P00533; P04085; P01127; Q9NRA1

Names & Taxonomy

Structure

Subcellular location

Function

Publication