Names & Taxonomy
- Uniprot ID:
- P16220
- Entry Name:
- CREB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
- Gene Names:
- CREB1
- Gene Names Primary:
- CREB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 341
- Sequence:
- MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
- Cross Reference Drug Bank:
- DB00131 DB01183
- Gene Ontology Go:
- ATF4-CREB1 transcription factor complex
axon
mitochondrial matrix
nuclear euchromatin
nucleoplasm
nucleus
cAMP response element binding
enzyme binding
identical protein binding
RNA polymerase II activating transcription factor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcription cofactor activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
activation of phospholipase C activity
aging
axon guidance
cellular response to fatty acid
cellular response to hepatocyte growth factor stimulus
cellular response to insulin-like growth factor stimulus
cellular response to nerve growth factor stimulus
cellular response to platelet-derived growth factor stimulus
cellular response to zinc ion
chemotaxis to arachidonic acid
circadian rhythm
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
lactation
lung saccule development
memory
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of neuron death
negative regulation of transcription by competitive promoter binding
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
phosphatidylinositol-mediated signaling
pituitary gland development
positive regulation of apoptotic process
positive regulation of fat cell differentiation
positive regulation of hormone secretion
positive regulation of lipid biosynthetic process
positive regulation of long-term synaptic potentiation
positive regulation of multicellular organism growth
positive regulation of osteoclast differentiation
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transforming growth factor beta3 production
protein phosphorylation
protein stabilization
regulation of cell size
regulation of circadian rhythm
regulation of fibroblast proliferation
regulation of glial cell proliferation
response to activity
response to antidepressant
response to glucagon
response to hypoxia
response to L-glutamate
response to nicotine
response to organic substance
secretory granule organization
signal transduction
stress-activated MAPK cascade
synaptic transmission
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transforming growth factor beta receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Type I pneumocyte differentiation
viral process
visual learning - Gene Ontology Biological Process:
- activation of phospholipase C activity
aging
axon guidance
cellular response to fatty acid
cellular response to hepatocyte growth factor stimulus
cellular response to insulin-like growth factor stimulus
cellular response to nerve growth factor stimulus
cellular response to platelet-derived growth factor stimulus
cellular response to zinc ion
chemotaxis to arachidonic acid
circadian rhythm
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
lactation
lung saccule development
memory
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of neuron death
negative regulation of transcription by competitive promoter binding
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
phosphatidylinositol-mediated signaling
pituitary gland development
positive regulation of apoptotic process
positive regulation of fat cell differentiation
positive regulation of hormone secretion
positive regulation of lipid biosynthetic process
positive regulation of long-term synaptic potentiation
positive regulation of multicellular organism growth
positive regulation of osteoclast differentiation
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transforming growth factor beta3 production
protein phosphorylation
protein stabilization
regulation of cell size
regulation of circadian rhythm
regulation of fibroblast proliferation
regulation of glial cell proliferation
response to activity
response to antidepressant
response to glucagon
response to hypoxia
response to L-glutamate
response to nicotine
response to organic substance
secretory granule organization
signal transduction
stress-activated MAPK cascade
synaptic transmission
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transforming growth factor beta receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Type I pneumocyte differentiation
viral process
visual learning - Gene Ontology Molecular Function:
- cAMP response element binding
enzyme binding
identical protein binding
RNA polymerase II activating transcription factor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription cofactor activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- ATF4-CREB1 transcription factor complex
axon
mitochondrial matrix
nuclear euchromatin
nucleoplasm
nucleus - Keywords:
- 3D-structure
Activator
Alternative splicing
Biological rhythms
Chromosomal rearrangement
Complete proteome
DNA-binding
Differentiation
Host-virus interaction
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- Itself; P03259-2; P18846; Q92793; Q09472; P0C746; Q9DGW5; O00470; O95644; Q13469; Q16649; Q96RG2; Q6SA08